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dc.contributor.authorStaudinger, Jeffrey Leonard
dc.contributor.authorWoody, Sarah K.
dc.contributor.authorSun, Mengxi
dc.contributor.authorCui, Wenqi
dc.identifier.citationStaudinger, J. L., Woody, S., Sun, M., & Cui, W. (2013). Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver. Drug Metabolism Reviews, 45(1), 48–59.
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in Drug Metabolism Reviews on 2015 Sep 2, available online:
dc.description.abstractAdverse drug events (ADEs) are a common cause of patient morbidity and mortality and are classically thought to result, in part, from variation in expression and activity of hepatic enzymes of drug metabolism. It is now known that alterations in the expression of genes that encode drug- and bile-acid–transporter proteins in both the gut and liver play a previously unrecognized role in determining patient drug response and eventual clinical outcome. Four nuclear receptor (NR) superfamily members, including pregnane X receptor (PXR, NR1I2), constitutive androstane receptor (NR1I3), farnesoid X receptor (NR1H4), and vitamin D receptor (NR1I1), play pivotal roles in drug- and bile-acid– activated programs of gene expression to coordinately regulate drug- and bile-acid transport activity in the intestine and liver. This review focuses on the NR-mediated gene activation of drug and bile-acid transporters in these tissues as well as the possible underlying molecular mechanisms.en_US
dc.publisherTaylor & Francisen_US
dc.subjectPregnane x receptoren_US
dc.subjectConstitutive androstane receptoren_US
dc.subjectFarnesoid x receptoren_US
dc.subjectVitamin D receptoren_US
dc.subjectLiver diseaseen_US
dc.subjectAdverse drug eventsen_US
dc.subjectDrug interactionsen_US
dc.titleNuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liveren_US
kusw.kuauthorStaudinger, Jeff L.
kusw.kuauthorWoody, Sarah
kusw.kuauthorSun, Mengxi
kusw.kuauthorCui, Wenqi
kusw.oanotesPer SHERPA/RoMEO 6/12/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions:

Some individual journals may have policies prohibiting pre-print archiving On author's personal website or departmental website immediately On institutional repository, subject-based repository or academic social network (Mendeley, ResearchGate or after 12 months embargo Publisher's version/PDF cannot be used On a non-profit server Published source must be acknowledged Must link to publisher version Set statements to accompany deposits (see policy) The publisher will deposit in on behalf of authors to a designated institutional repository including PubMed Central, where a deposit agreement exists with the repository
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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