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    Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver

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    Staudinger_2013.pdf (1010.Kb)
    Issue Date
    2013-02
    Author
    Staudinger, Jeffrey Leonard
    Woody, Sarah K.
    Sun, Mengxi
    Cui, Wenqi
    Publisher
    Taylor & Francis
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Metadata
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    Abstract
    Adverse drug events (ADEs) are a common cause of patient morbidity and mortality and are classically thought to result, in part, from variation in expression and activity of hepatic enzymes of drug metabolism. It is now known that alterations in the expression of genes that encode drug- and bile-acid–transporter proteins in both the gut and liver play a previously unrecognized role in determining patient drug response and eventual clinical outcome. Four nuclear receptor (NR) superfamily members, including pregnane X receptor (PXR, NR1I2), constitutive androstane receptor (NR1I3), farnesoid X receptor (NR1H4), and vitamin D receptor (NR1I1), play pivotal roles in drug- and bile-acid– activated programs of gene expression to coordinately regulate drug- and bile-acid transport activity in the intestine and liver. This review focuses on the NR-mediated gene activation of drug and bile-acid transporters in these tissues as well as the possible underlying molecular mechanisms.
    Description
    This is an Accepted Manuscript of an article published by Taylor & Francis in Drug Metabolism Reviews on 2015 Sep 2, available online: http://www.tandfonline.com/10.3109/03602532.2012.748793.
    URI
    http://hdl.handle.net/1808/24466
    DOI
    https://doi.org/10.3109/03602532.2012.748793
    Collections
    • Pharmacy Scholarly Works [280]
    Citation
    Staudinger, J. L., Woody, S., Sun, M., & Cui, W. (2013). Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver. Drug Metabolism Reviews, 45(1), 48–59. http://doi.org/10.3109/03602532.2012.748793

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    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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