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dc.contributor.authorAnderson, Christa J.
dc.contributor.authorColombo, John
dc.contributor.authorUnruh, Kathryn E.
dc.date.accessioned2017-06-12T15:59:55Z
dc.date.available2017-06-12T15:59:55Z
dc.date.issued2013-07
dc.identifier.citationAnderson, C. J., Colombo, J., & Unruh, K. E. (2013). Pupil and Salivary Indicators of Autonomic Dysfunction in Autism Spectrum Disorder. Developmental Psychobiology, 55(5), 10.1002/dev.21051. http://doi.org/10.1002/dev.21051en_US
dc.identifier.urihttp://hdl.handle.net/1808/24465
dc.descriptionThis is the peer reviewed version of the following article: Anderson, C. J., Colombo, J. and Unruh, K. E. (2013), Pupil and salivary indicators of autonomic dysfunction in autism spectrum disorder. Dev. Psychobiol., 55: 465–482. doi:10.1002/dev.21051, which has been published in final form at http://doi.org/10.1002/dev.21051. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.description.abstractDysregulated tonic pupil size has been reported in Autism Spectrum Disorder (ASD). Among the possible sources of this dysregulation are disruptions in the feedback loop between norepinephrine (NE) and hypothalamic systems. In the current study, we examined afternoon levels of salivary alpha-amylase (sAA, a putative correlate of NE) and cortisol (used to assess stress-based responses) in two independent samples of children with ASD. We found a larger pupil size and lower sAA levels in ASD, compared to typical and clinical age-matched controls. This was substantiated at the individual level, as sAA levels were strongly correlated with tonic pupil size. Relatively little diurnal variation in sAA taken in the home environment in the ASD group was also observed, while typical controls showed a significant linear increase throughout the day. Results are discussed in terms of potential early biomarkers and the elucidation of underlying neural dysfunction in ASD.en_US
dc.publisherWileyen_US
dc.subjectAutism Spectrum Disorderen_US
dc.subjectAutonomic Nervous Systemen_US
dc.subjectPupil Sizeen_US
dc.subjectNorepinephrineen_US
dc.subjectAlpha-amylaseen_US
dc.subjectCortisolen_US
dc.subjectEye-Trackingen_US
dc.titlePupil and Salivary Indicators of Autonomic Dysfunction in Autism Spectrum Disorderen_US
dc.typeArticleen_US
kusw.kuauthorAnderson, Christa J.
kusw.kuauthorColombo, John
kusw.kuauthorUnruh, Kathryn E.
kusw.kudepartmentLife Span Institueen_US
dc.identifier.doi10.1002/dev.21051en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC3832142en_US
dc.rights.accessrightsopenAccess


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