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    Cardiorespiratory fitness and preserved medial temporal lobe volume in Alzheimer's Disease

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    Donnelly_2009.pdf (617.2Kb)
    Issue Date
    2009
    Author
    Honea, Robyn A.
    Thomas, George Patrick, Jr.
    Harsha, Amith
    Anderson, Heather S.
    Donnelly, Joseph E.
    Brooks, William M.
    Burns, Jeffrey M.
    Publisher
    Lippincott, Williams & Wilkins
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Exercise and cardiorespiratory (CR) fitness may moderate age-related regional brain changes in nondemented older adults (ND). The relationship of fitness to Alzheimer's disease (AD) related brain change is understudied, particularly in the hippocampus which is disproportionately affected in early AD. The role of apolipoprotein E4 (apoE4) genotype in modulating this relationship is also unknown. Nondemented (n=56) and early-stage AD subjects (n=61) over age 65 had MRI and CR fitness assessments. Voxel-based morphometry (VBM) techniques were utilized to identify AD-related atrophy. We analyzed the relationship of CR fitness with white and gray matter within groups, assessed fitness-related brain volume change in areas most affected by AD-related atrophy, and then analyzed differential fitness-brain relationships between apoE4 carriers. Atrophy was present in the medial temporal, temporal, and parietal cortices in subjects with mild AD. There was a significant positive correlation of CR fitness with parietal and medial temporal volume in AD subjects. ND subjects did not have a significant relationship between brain volume and CR fitness in the global or SVC analyses. There was not a significant interaction for fitness × apoE4 genotype in either group. In early-stage AD, cardiorespiratory fitness is associated with regional brain volumes in the medial temporal and parietal cortices suggesting that maintaining cardiorespiratory fitness may modify AD-related brain atrophy.
    Description
    This is not the final published version.
    URI
    http://hdl.handle.net/1808/24320
    DOI
    https://doi.org/10.1097/WAD.0b013e31819cb8a2
    Collections
    • Life Span Institute Scholarly Works [127]
    Citation
    Honea, R., Thomas, G. P., Harsha, A., Anderson, H. S., Donnelly, J. E., Brooks, W. M., & Burns, J. M. (2009). Cardiorespiratory fitness and preserved medial temporal lobe volume in Alzheimer’s Disease. Alzheimer Disease and Associated Disorders, 23(3), 188–197. http://doi.org/10.1097/WAD.0b013e31819cb8a2

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    KU Libraries
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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