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dc.contributor.authorGraham, Zachary Aaron
dc.contributor.authorGallagher, Philip M.
dc.contributor.authorCardozo, Christopher P.
dc.date.accessioned2017-05-24T17:10:16Z
dc.date.available2017-05-24T17:10:16Z
dc.date.issued2015-10
dc.identifier.citationGraham, Z. A., Gallagher, P. M., & Cardozo, C. P. (2015). Focal adhesion kinase and its role in skeletal muscle. Journal of Muscle Research and Cell Motility, 36(0), 305–315. http://doi.org/10.1007/s10974-015-9415-3en_US
dc.identifier.urihttp://hdl.handle.net/1808/24295
dc.description.abstractSkeletal muscle has a remarkable ability to respond to different physical stresses. Loading muscle through exercise, either anaerobic or aerobic, can lead to increases in muscle size and function while, conversely, the absence of muscle loading stimulates rapid decreases in size and function. A principal mediator of this load-induced change is focal adhesion kinase (FAK), a downstream non-receptor tyrosine kinase that translates the cytoskeletal stress and strain signals transmitted across the cytoplasmic membrane by integrins to activate multiple anti-apoptotic and cell growth pathways. Changes in FAK expression and phosphorylation have been found to correlate to specific developmental states in myoblast differentiation, muscle fiber formation and muscle size in response to loading and unloading. With the capability to regulate costamere formation, hypertrophy and glucose metabolism, FAK is a molecule with diverse functions that are important in regulating muscle cell health.en_US
dc.publisherSpringer Verlagen_US
dc.rights© Springer International Publishing Switzerland (outside the USA) 2015en_US
dc.subjectFocal adhesion kinaseen_US
dc.subjectHypertrophyen_US
dc.subjectMuscle developmenten_US
dc.subjectExcerciseen_US
dc.titleFocal adhesion kinase and its role in skeletal muscleen_US
dc.typeArticleen_US
kusw.kuauthorGallagher, Philip M.
kusw.kudepartmentHealth, Sport, and Exercise Sciencesen_US
dc.identifier.doi10.1007/s10974-015-9415-3en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4659753en_US
dc.rights.accessrightsopenAccess


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