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    Focal adhesion kinase and its role in skeletal muscle

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    Gallagher_2015.pdf (531.1Kb)
    Issue Date
    2015-10
    Author
    Graham, Zachary Aaron
    Gallagher, Philip M.
    Cardozo, Christopher P.
    Publisher
    Springer Verlag
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    © Springer International Publishing Switzerland (outside the USA) 2015
    Metadata
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    Abstract
    Skeletal muscle has a remarkable ability to respond to different physical stresses. Loading muscle through exercise, either anaerobic or aerobic, can lead to increases in muscle size and function while, conversely, the absence of muscle loading stimulates rapid decreases in size and function. A principal mediator of this load-induced change is focal adhesion kinase (FAK), a downstream non-receptor tyrosine kinase that translates the cytoskeletal stress and strain signals transmitted across the cytoplasmic membrane by integrins to activate multiple anti-apoptotic and cell growth pathways. Changes in FAK expression and phosphorylation have been found to correlate to specific developmental states in myoblast differentiation, muscle fiber formation and muscle size in response to loading and unloading. With the capability to regulate costamere formation, hypertrophy and glucose metabolism, FAK is a molecule with diverse functions that are important in regulating muscle cell health.
    URI
    http://hdl.handle.net/1808/24295
    DOI
    https://doi.org/10.1007/s10974-015-9415-3
    Collections
    • Health, Sport & Exercise Sciences Scholarly Works [111]
    Citation
    Graham, Z. A., Gallagher, P. M., & Cardozo, C. P. (2015). Focal adhesion kinase and its role in skeletal muscle. Journal of Muscle Research and Cell Motility, 36(0), 305–315. http://doi.org/10.1007/s10974-015-9415-3

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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