A One-Pot, 3 Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1, 1-Dioxido-1, 2-benzisothiazoline-2-acetic acids

Rolfe, Alan; Young, Kyle; Volp, Kelly; Schoenen, Frank J.; Neuenswander, Benjamin; Lushington, Gerald H.; Hanson, Paul R.

dc.contributor.author	Rolfe, Alan
dc.contributor.author	Young, Kyle
dc.contributor.author	Volp, Kelly
dc.contributor.author	Schoenen, Frank J.
dc.contributor.author	Neuenswander, Benjamin
dc.contributor.author	Lushington, Gerald H.
dc.contributor.author	Hanson, Paul R.
dc.date.accessioned	2017-05-22T16:02:59Z
dc.date.available	2017-05-22T16:02:59Z
dc.date.issued	2009
dc.identifier.citation	Rolfe, A., Young, K., Volp, K., Schoenen, F., Neuenswander, B., Lushington, G. H., & Hanson, P. R. (2009). A One-Pot, 3-Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1,1-Dioxido-1,2-benzisothiazoline-3-acetic acids. Journal of Combinatorial Chemistry, 11(4), 732–738. http://doi.org/10.1021/cc900025e	en_US
dc.identifier.uri	http://hdl.handle.net/1808/24255
dc.description	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc900025e.	en_US
dc.description.abstract	A sequential three-component synthesis of functionalized benzisothiazoline-3-acetic acid 1,1- dioxides utilizing a domino Heck-aza-Michael pathway is reported. This one-pot procedure rapidly assembles functionalized benzylsulfonamides, which undergo a palladium-catalyzed, domino, Heckaza- Michael transformation in an experimentally straightforward manner. This attractive protocol has been utilized to synthesize three combinatorial sub-libraries (I-III) comprising a total of 95 compounds in high purities (≥95% for 75 compounds), yield and quantities.	en_US
dc.publisher	American Chemical Society	en_US
dc.rights	Copyright © American Chemical Society	en_US
dc.subject	Domino	en_US
dc.subject	Heck	en_US
dc.subject	Aza-Michael	en_US
dc.subject	Sultam	en_US
dc.title	A One-Pot, 3 Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1, 1-Dioxido-1, 2-benzisothiazoline-2-acetic acids	en_US
dc.type	Article	en_US
kusw.kuauthor	Rolfe, Alan
kusw.kuauthor	Young, Kyle
kusw.kuauthor	Volp, Kelly
kusw.kuauthor	Schoenen, Frank
kusw.kuauthor	Neuenswander, Benjamin
kusw.kuauthor	Lushington, Gerald H.
kusw.kuauthor	Hanson, Paul R.
kusw.kudepartment	Chemistry	en_US
dc.identifier.doi	10.1021/cc900025e	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.identifier.pmid	PMC2895961	en_US
dc.rights.accessrights	openAccess

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