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A One-Pot, 3 Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1, 1-Dioxido-1, 2-benzisothiazoline-2-acetic acids

dc.contributor.authorRolfe, Alan
dc.contributor.authorYoung, Kyle
dc.contributor.authorVolp, Kelly
dc.contributor.authorSchoenen, Frank J.
dc.contributor.authorNeuenswander, Benjamin
dc.contributor.authorLushington, Gerald H.
dc.contributor.authorHanson, Paul R.
dc.date.accessioned2017-05-22T16:02:59Z
dc.date.available2017-05-22T16:02:59Z
dc.date.issued2009
dc.identifier.citationRolfe, A., Young, K., Volp, K., Schoenen, F., Neuenswander, B., Lushington, G. H., & Hanson, P. R. (2009). A One-Pot, 3-Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1,1-Dioxido-1,2-benzisothiazoline-3-acetic acids. Journal of Combinatorial Chemistry, 11(4), 732–738. http://doi.org/10.1021/cc900025een_US
dc.identifier.urihttp://hdl.handle.net/1808/24255
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc900025e.en_US
dc.description.abstractA sequential three-component synthesis of functionalized benzisothiazoline-3-acetic acid 1,1- dioxides utilizing a domino Heck-aza-Michael pathway is reported. This one-pot procedure rapidly assembles functionalized benzylsulfonamides, which undergo a palladium-catalyzed, domino, Heckaza- Michael transformation in an experimentally straightforward manner. This attractive protocol has been utilized to synthesize three combinatorial sub-libraries (I-III) comprising a total of 95 compounds in high purities (≥95% for 75 compounds), yield and quantities.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsCopyright © American Chemical Societyen_US
dc.subjectDominoen_US
dc.subjectHecken_US
dc.subjectAza-Michaelen_US
dc.subjectSultamen_US
dc.titleA One-Pot, 3 Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1, 1-Dioxido-1, 2-benzisothiazoline-2-acetic acidsen_US
dc.typeArticleen_US
kusw.kuauthorRolfe, Alan
kusw.kuauthorYoung, Kyle
kusw.kuauthorVolp, Kelly
kusw.kuauthorSchoenen, Frank
kusw.kuauthorNeuenswander, Benjamin
kusw.kuauthorLushington, Gerald H.
kusw.kuauthorHanson, Paul R.
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1021/cc900025een_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2895961en_US
dc.rights.accessrightsopenAccess


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