Show simple item record

dc.contributor.authorStanford, John A.
dc.contributor.authorShuler, Jeffrey M.
dc.contributor.authorFowler, Stephen C.
dc.contributor.authorStanford, Kimberly G.
dc.contributor.authorMa, Delin
dc.contributor.authorBittel, Douglas C.
dc.contributor.authorLe Pichon, Jean-Baptiste
dc.identifier.citationStanford, John A. et al. “Hyperactivity in the Gunn Rat Model of Neonatal Jaundice: Age-Related Attenuation and Emergence of Gait Deficits.” Pediatric research 77.3 (2015): 434–439.en_US

Neonatal jaundice resulting from elevated unconjugated bilirubin (UCB) occurs in 60–80% of newborn infants. Although mild jaundice is generally considered harmless, little is known about its long-term consequences. Recent studies have linked mild bilirubin-induced neurological dysfunction (BIND) with a range of neurological syndromes, including attention deficit-hyperactivity disorder. The goal of this study was to measure BIND across the lifespan in the Gunn rat model of BIND.


Using a sensitive force plate actometer, we measured locomotor activity and gait in jaundiced (jj) Gunn rats versus their non-jaundiced (Nj) littermates. Data were analyzed for young adult (3–4 months), early middle-aged (9–10 months), and late middle-aged (17–20 months) male rats.


jj rats exhibited lower body weights at all ages and a hyperactivity that resolved at 17–20 months of age. Increased propulsive force and gait velocity accompanied hyperactivity during locomotor bouts at 9–10 months in jj rats. Stride length did not differ between the two groups at this age. Hyperactivity normalized and gait deficits, including decreased stride length, propulsive force, and gait velocity, emerged in the 17–20-month-old jj rats.


These results demonstrate that, in aging, hyperactivity decreases with the onset of gait deficits in the Gunn rat model of BIND.
dc.publisherNature Publishing Groupen_US
dc.titleHyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficitsen_US
kusw.kuauthorFowler, Stephen C.
kusw.kudepartmentPharmacology & Toxicologyen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record