Show simple item record

dc.contributor.authorPrasasty, Vivitri D.
dc.contributor.authorKrause, Mary Elizabeth
dc.contributor.authorTambunan, Usman S. F.
dc.contributor.authorAnbanandam, Asokan
dc.contributor.authorLaurence, Jennifer S.
dc.contributor.authorSiahaan, Teruna J.
dc.date.accessioned2017-05-10T17:29:49Z
dc.date.available2017-05-10T17:29:49Z
dc.date.issued2014-02-08
dc.identifier.citationPrasasty, V. D., Krause, M. E., Tambunan, U. S. F., Anbanandam, A., Laurence, J. S., & Siahaan, T. J. (2015). 1H, 13C and 15N Backbone Assignment of the EC-1 Domain of Human E-Cadherin. Biomolecular NMR Assignments, 9(1), 31–35. http://doi.org/10.1007/s12104-013-9539-6en_US
dc.identifier.urihttp://hdl.handle.net/1808/24071
dc.descriptionThe final publication is available at Springer via http://dx.doi.org/10.1007/s12104-013-9539-6en_US
dc.description.abstractThe EC1 domain of E-cadherin has been shown to be important for cadherin-cadherin homophilic interactions. Cadherins are responsible for calcium-mediated cell-cell adhesion located at the adherens junction of the biological barriers (i.e., intestinal mucosa and the blood-brain barrier (BBB). Cadherin peptides can modulate cadherin interactions to improve drug delivery through the blood-brain barriers (BBB). However, the mechanism of modulating the E-cadherin interactions by cadherin peptides has not been fully elucidated. To provide a basis for subsequent examination of the structure and peptide-binding properties of the EC1 domain of human E-cadherin using solution NMR spectroscopy, the 1H, 13C and 15N backbone resonance of the uniformly labeled-EC1 were assigned and the secondary structure was determined based on the chemical shift values. These resonance assignments are essential for assessing protein-ligand interactions and are reported here.en_US
dc.publisherSpringer Verlagen_US
dc.rights© Springer Science+Business Media Dordrecht 2014en_US
dc.subjectHuman E-cadherinen_US
dc.subjectEC1en_US
dc.subjectBackbone resonance assignmenten_US
dc.subjectMultidimensional NMRen_US
dc.title1H, 13C and 15N Backbone Assignment of the EC-1 Domain of Human E-Cadherinen_US
dc.typeArticleen_US
kusw.kuauthorPrasasty, Vivitri D.
kusw.kuauthorKrause, Mary E.
kusw.kuauthorLaurence, Jennifer S.
kusw.kuauthorSiahaan, Teruna J.
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1007/s12104-013-9539-6en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4133310en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record