ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated. If you have any questions, please contact Marianne Reed at .

Show simple item record

dc.contributor.authorPrasasty, Vivitri D.
dc.contributor.authorKrause, Mary Elizabeth
dc.contributor.authorTambunan, Usman S. F.
dc.contributor.authorAnbanandam, Asokan
dc.contributor.authorLaurence, Jennifer S.
dc.contributor.authorSiahaan, Teruna J.
dc.identifier.citationPrasasty, V. D., Krause, M. E., Tambunan, U. S. F., Anbanandam, A., Laurence, J. S., & Siahaan, T. J. (2015). 1H, 13C and 15N Backbone Assignment of the EC-1 Domain of Human E-Cadherin. Biomolecular NMR Assignments, 9(1), 31–35.
dc.descriptionThe final publication is available at Springer via
dc.description.abstractThe EC1 domain of E-cadherin has been shown to be important for cadherin-cadherin homophilic interactions. Cadherins are responsible for calcium-mediated cell-cell adhesion located at the adherens junction of the biological barriers (i.e., intestinal mucosa and the blood-brain barrier (BBB). Cadherin peptides can modulate cadherin interactions to improve drug delivery through the blood-brain barriers (BBB). However, the mechanism of modulating the E-cadherin interactions by cadherin peptides has not been fully elucidated. To provide a basis for subsequent examination of the structure and peptide-binding properties of the EC1 domain of human E-cadherin using solution NMR spectroscopy, the 1H, 13C and 15N backbone resonance of the uniformly labeled-EC1 were assigned and the secondary structure was determined based on the chemical shift values. These resonance assignments are essential for assessing protein-ligand interactions and are reported here.en_US
dc.publisherSpringer Verlagen_US
dc.rights© Springer Science+Business Media Dordrecht 2014en_US
dc.subjectHuman E-cadherinen_US
dc.subjectBackbone resonance assignmenten_US
dc.subjectMultidimensional NMRen_US
dc.title1H, 13C and 15N Backbone Assignment of the EC-1 Domain of Human E-Cadherinen_US
kusw.kuauthorPrasasty, Vivitri D.
kusw.kuauthorKrause, Mary E.
kusw.kuauthorLaurence, Jennifer S.
kusw.kuauthorSiahaan, Teruna J.
kusw.kudepartmentPharmaceutical Chemistryen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record