Show simple item record

dc.contributor.authorSchneider, Erich H.
dc.contributor.authorFowler, Stephen C.
dc.contributor.authorLionakis, Michail S.
dc.contributor.authorSwamydas, Muthulekha
dc.contributor.authorHolmes, Gibran
dc.contributor.authorDiaz, Vivian
dc.contributor.authorMunasinghe, Jeeva
dc.contributor.authorPeiper, Stephen C.
dc.contributor.authorGao, Ji-Liang
dc.contributor.authorMurphy, Philip M.
dc.date.accessioned2017-05-10T17:03:56Z
dc.date.available2017-05-10T17:03:56Z
dc.date.issued2014-09
dc.identifier.citationSchneider, E. H., Fowler, S. C., Lionakis, M. S., Swamydas, M., Holmes, G., Diaz, V., … Murphy, P. M. (2014). Regulation of Motor Function and Behavior by Atypical Chemokine Receptor 1. Behavior Genetics, 44(5), 498–515. http://doi.org/10.1007/s10519-014-9665-7en_US
dc.identifier.urihttp://hdl.handle.net/1808/24068
dc.descriptionThe final publication is available at Springer via http://dx.doi.org/10.1007/s10519-014-9665-7en_US
dc.description.abstractAtypical Chemokine Receptor 1 (ACKR1), previously known as the Duffy Antigen Receptor for Chemokines, stands out among chemokine receptors for its high selective expression on Purkinje cells of the cerebellum, consistent with the ability of ACKR1 ligands to activate Purkinje cells in vitro. Nevertheless, evidence for ACKR1 regulation of brain function in vivo has been lacking. Here we demonstrate that Ackr1−/− mice have markedly impaired balance and ataxia when placed on a rotating rod and increased tremor when injected with harmaline, a drug that induces whole-body tremor by activating Purkinje cells. Ackr1−/− mice also exhibited impaired exploratory behavior, increased anxiety-like behavior and frequent episodes of marked hypoactivity under low-stress conditions. The behavioral phenotype of Ackr1−/− mice was the opposite of the phenotype occurring in mice with cerebellar degeneration and the defects persisted when Ackr1 was deficient only on non-hematopoietic cells. We conclude that normal motor function and behavior depend in part on negative regulation of Purkinje cell activity by Ackr1.en_US
dc.publisherSpringer Verlagen_US
dc.rights© Springer Science+Business Media New York (outside the USA) 2014en_US
dc.titleRegulation of Motor Function and Behavior by Atypical Chemokine Receptor 1en_US
dc.typeArticleen_US
kusw.kuauthorFowler, Stephen C.
kusw.kudepartmentPharmacology and Toxicologyen_US
dc.identifier.doi10.1007/s10519-014-9665-7en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4790732en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record