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Light-induced Conversion of Trp to Gly and Gly Hydroperoxide in IgG1
dc.contributor.author | Haywood, Jessica | |
dc.contributor.author | Mozziconacci, Olivier | |
dc.contributor.author | Allegre, Kevin M. | |
dc.contributor.author | Kerwin, Bruce A. | |
dc.contributor.author | Schöneich, Christian | |
dc.date.accessioned | 2017-05-09T20:26:33Z | |
dc.date.available | 2017-05-09T20:26:33Z | |
dc.date.issued | 2013-03-04 | |
dc.identifier.citation | Haywood, J., Mozziconacci, O., Allegre, K. M., Kerwin, B. A., & Schöneich, C. (2013). Light-induced Conversion of Trp to Gly and Gly Hydroperoxide in IgG1. Molecular Pharmaceutics, 10(3), 1146–1150. http://doi.org/10.1021/mp300680c | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24057 | |
dc.description.abstract | The exposure of IgG1 in aqueous solution to light with λ = 254 nm or λ > 295 nm yields products consistent with Trp radical cation formation followed by αC-βC cleavage of the Trp side chain. The resulting glycyl radicals are either reduced to Gly, or add oxygen prior to reduction to Gly hydroperoxide. Photoirradiation at λ = 254 nm targets Trp at positions 191 (light chain), 309 and 377 (heavy chain) while photoirradiation at λ > 295 nm targets Trp at position 309 (heavy chain). Mechanistically, the formation of Trp radical cations likely proceeds via photo-induced electron- or hydrogen-transfer to disulfide bonds, yielding thiyl radicals and thiols, where thiols may serve as reductants for the intermediary glycyl or glycylperoxyl radicals. | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/mp1000718. | en_US |
dc.subject | Immunoglobulin | en_US |
dc.subject | IgG1 | en_US |
dc.subject | Tryptophan | en_US |
dc.subject | Photochemistry | en_US |
dc.subject | Glycine radical | en_US |
dc.subject | Hydroperoxide | en_US |
dc.title | Light-induced Conversion of Trp to Gly and Gly Hydroperoxide in IgG1 | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Haywood, Jessica | |
kusw.kuauthor | Mozziconacci, Olivier | |
kusw.kuauthor | Allegre, Kevin M. | |
kusw.kuauthor | Kerwin, Bruce A. | |
kusw.kuauthor | Schöneich, Christian | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.1021/mp300680c | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC3632305 | en_US |
dc.rights.accessrights | openAccess |