ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated. If you have any questions, please contact Marianne Reed at mreed@ku.edu .

Show simple item record

dc.contributor.authorHaywood, Jessica
dc.contributor.authorMozziconacci, Olivier
dc.contributor.authorAllegre, Kevin M.
dc.contributor.authorKerwin, Bruce A.
dc.contributor.authorSchöneich, Christian
dc.date.accessioned2017-05-09T20:26:33Z
dc.date.available2017-05-09T20:26:33Z
dc.date.issued2013-03-04
dc.identifier.citationHaywood, J., Mozziconacci, O., Allegre, K. M., Kerwin, B. A., & Schöneich, C. (2013). Light-induced Conversion of Trp to Gly and Gly Hydroperoxide in IgG1. Molecular Pharmaceutics, 10(3), 1146–1150. http://doi.org/10.1021/mp300680cen_US
dc.identifier.urihttp://hdl.handle.net/1808/24057
dc.description.abstractThe exposure of IgG1 in aqueous solution to light with λ = 254 nm or λ > 295 nm yields products consistent with Trp radical cation formation followed by αC-βC cleavage of the Trp side chain. The resulting glycyl radicals are either reduced to Gly, or add oxygen prior to reduction to Gly hydroperoxide. Photoirradiation at λ = 254 nm targets Trp at positions 191 (light chain), 309 and 377 (heavy chain) while photoirradiation at λ > 295 nm targets Trp at position 309 (heavy chain). Mechanistically, the formation of Trp radical cations likely proceeds via photo-induced electron- or hydrogen-transfer to disulfide bonds, yielding thiyl radicals and thiols, where thiols may serve as reductants for the intermediary glycyl or glycylperoxyl radicals.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/mp1000718.en_US
dc.subjectImmunoglobulinen_US
dc.subjectIgG1en_US
dc.subjectTryptophanen_US
dc.subjectPhotochemistryen_US
dc.subjectGlycine radicalen_US
dc.subjectHydroperoxideen_US
dc.titleLight-induced Conversion of Trp to Gly and Gly Hydroperoxide in IgG1en_US
dc.typeArticleen_US
kusw.kuauthorHaywood, Jessica
kusw.kuauthorMozziconacci, Olivier
kusw.kuauthorAllegre, Kevin M.
kusw.kuauthorKerwin, Bruce A.
kusw.kuauthorSchöneich, Christian
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1021/mp300680cen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC3632305en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record