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dc.contributor.authorScott, David E.
dc.contributor.authorGrigsby, Ryan
dc.contributor.authorLunte, Susan M.
dc.date.accessioned2017-05-08T18:38:53Z
dc.date.available2017-05-08T18:38:53Z
dc.date.issued2013-07-22
dc.identifier.citationScott, D. E., Grigsby, R., & Lunte, S. M. (2013). Microdialysis Sampling Coupled to Microchip Electrophoresis with Integrated Amperometric Detection on an All Glass Substrate. Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry, 14(10), 2288–2294. http://doi.org/10.1002/cphc.201300449en_US
dc.identifier.urihttp://hdl.handle.net/1808/24021
dc.descriptionThis is the peer reviewed version of the following article: Scott, D. E., Grigsby, R., & Lunte, S. M. (2013). Microdialysis Sampling Coupled to Microchip Electrophoresis with Integrated Amperometric Detection on an All Glass Substrate. Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry, 14(10), 2288–2294. http://doi.org/10.1002/cphc.201300449, which has been published in final form at doi.org/10.1002/cphc.201300449. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.description.abstractThe development of an all-glass separation-based sensor using microdialysis coupled to microchip electrophoresis with amperometric detection is described. The system includes a flow-gated interface to inject discrete sample plugs from the microdialysis perfusate into the microchip electrophoresis system. Electrochemical detection was accomplished with a platinum electrode in an in-channel configuration using a wireless electrically isolated potentiostat. To facilitate bonding around the in-channel electrode, a fabrication process was employed that produced a working and a reference electrode flush with the glass surface. Both normal and reversed polarity separations were performed with this sensor. The system was evaluated in vitro for the continuous monitoring of the production of hydrogen peroxide from the reaction of glucose oxidase with glucose. Microdialysis experiments were performed using a BASi loop probe with an overall lag time of approximately five minutes and a rise time of less than 60 seconds.en_US
dc.publisherWileyen_US
dc.rights© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimen_US
dc.subjectGlass microchipen_US
dc.subjectElectrochemical detectionen_US
dc.subjectMicrochip electrophoresisen_US
dc.subjectMicrodialysisen_US
dc.subjectMicrofluidicsen_US
dc.titleMicrodialysis Sampling Coupled to Microchip Electrophoresis with Integrated Amperometric Detection on an All Glass Substrateen_US
dc.typeArticleen_US
kusw.kuauthorScott, David E.
kusw.kuauthorGrigsby, Ryan
kusw.kuauthorLunte, Susan M.
kusw.kudepartmentChemistryen_US
kusw.kudepartmentPharmaceutical Chemistryen_US
kusw.kudepartmentRalph N. Adams Institute for Bioanalytical Chemistryen_US
dc.identifier.doi10.1002/cphc.201300449en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4000424en_US
dc.rights.accessrightsopenAccess


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