ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys and Gly
| dc.contributor.author | Mozziconacci, Olivier | |
| dc.contributor.author | Williams, Todd D. | |
| dc.contributor.author | Schöneich, Christian | |
| dc.date.accessioned | 2017-05-08T16:16:28Z | |
| dc.date.available | 2017-05-08T16:16:28Z | |
| dc.date.issued | 2012-09-17 | |
| dc.identifier.citation | Mozziconacci, O., Williams, T. D., & Schöneich, C. (2012). Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys and Gly. Chemical Research in Toxicology, 25(9), 1842–1861. http://doi.org/10.1021/tx3000494 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/24001 | |
| dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemical Research in Toxicology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/tx3000494 | en_US |
| dc.description.abstract | Glutathione thiyl radicals (GS•) were generated in H2O and D2O by either exposure of GSH to AAPH#, photoirradiation of GSH in the presence of acetone, or photoirradiation of GSSG. Detailed interpretation of the fragmentation pathways of deuterated GSH and GSH-derivatives during mass spectrometry analysis allowed us to demonstrate that reversible intramolecular H-atom transfer reactions between GS• and C-H bonds at Cys[αC], Cys[βC], and Gly[αC] are possible. | en_US |
| dc.publisher | ACS | en_US |
| dc.rights | © 2012 American Chemical Society | en_US |
| dc.subject | Glutathione | en_US |
| dc.subject | Thiyl radicals | en_US |
| dc.subject | C-centered radical | en_US |
| dc.subject | Hydrogen transfer | en_US |
| dc.subject | Mass spectrometry | en_US |
| dc.title | Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys and Gly | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Mozziconacci, Olivier | |
| kusw.kuauthor | Schöneich, Christian | |
| kusw.kuauthor | Williams, Todd D. | |
| kusw.kudepartment | Pharmaceutical Chemistry | en_US |
| kusw.kudepartment | Laboratory of Mass Spectrometry | en_US |
| dc.identifier.doi | 10.1021/tx3000494 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC3736831 | en_US |
| dc.rights.accessrights | openAccess |
