| dc.contributor.author | Mozziconacci, Olivier | |
| dc.contributor.author | Williams, Todd D. | |
| dc.contributor.author | Schöneich, Christian | |
| dc.date.accessioned | 2017-05-08T16:16:28Z | |
| dc.date.available | 2017-05-08T16:16:28Z | |
| dc.date.issued | 2012-09-17 | |
| dc.identifier.citation | Mozziconacci, O., Williams, T. D., & Schöneich, C. (2012). Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys and Gly. Chemical Research in Toxicology, 25(9), 1842–1861. http://doi.org/10.1021/tx3000494 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/24001 | |
| dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in
Chemical Research in Toxicology, copyright © American Chemical Society after peer review and technical editing by the publisher.
To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/tx3000494 | en_US |
| dc.description.abstract | Glutathione thiyl radicals (GS•) were generated in H2O and D2O by either exposure of GSH to AAPH#, photoirradiation of GSH in the presence of acetone, or photoirradiation of GSSG. Detailed interpretation of the fragmentation pathways of deuterated GSH and GSH-derivatives during mass spectrometry analysis allowed us to demonstrate that reversible intramolecular H-atom transfer reactions between GS• and C-H bonds at Cys[αC], Cys[βC], and Gly[αC] are possible. | en_US |
| dc.publisher | ACS | en_US |
| dc.rights | © 2012 American Chemical Society | en_US |
| dc.subject | Glutathione | en_US |
| dc.subject | Thiyl radicals | en_US |
| dc.subject | C-centered radical | en_US |
| dc.subject | Hydrogen transfer | en_US |
| dc.subject | Mass spectrometry | en_US |
| dc.title | Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys and Gly | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Mozziconacci, Olivier | |
| kusw.kuauthor | Schöneich, Christian | |
| kusw.kuauthor | Williams, Todd D. | |
| kusw.kudepartment | Pharmaceutical Chemistry | en_US |
| kusw.kudepartment | Laboratory of Mass Spectrometry | en_US |
| dc.identifier.doi | 10.1021/tx3000494 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC3736831 | en_US |
| dc.rights.accessrights | openAccess | |
