| dc.contributor.author | Fakhari, Amir | |
| dc.contributor.author | Berkland, Cory J. | |
| dc.date.accessioned | 2017-04-27T18:38:53Z | |
| dc.date.available | 2017-04-27T18:38:53Z | |
| dc.date.issued | 2013-07 | |
| dc.identifier.citation | Fakhari, A., & Berkland, C. (2013). Applications and Emerging Trends of Hyaluronic Acid in Tissue Engineering, as a Dermal Filler, and in Osteoarthritis Treatment. Acta Biomaterialia, 9(7), 7081–7092. http://doi.org/10.1016/j.actbio.2013.03.005 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23842 | |
| dc.description.abstract | Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of applications in medicine including scaffolding for tissue engineering, dermatological fillers, and viscosupplementation for osteoarthritis treatment. HA is available in most connective tissues in body fluids such as synovial fluid and the vitreous humor of the eye. HA is responsible for several structural properties of tissues as a component of extracellular matrix (ECM) and is involved in cellular signaling. Degradation of HA is a step-wise process that can occur via enzymatic or non-enzymatic reactions. A reduction in HA mass or molecular weight via degradation or slowing of synthesis affects physical and chemical properties such as tissue volume, viscosity, and elasticity. This review addresses the distribution, turnover, and tissue-specific properties of HA. This information is used as context for considering recent products and strategies for modifying the viscoelastic properties of HA in tissue engineering, as a dermal filler, and in osteoarthritis treatment. | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved | en_US |
| dc.subject | Hyaluronic acid | en_US |
| dc.subject | Crosslinking | en_US |
| dc.subject | Dermal filler | en_US |
| dc.subject | Viscosupplement | en_US |
| dc.title | Applications and Emerging Trends of Hyaluronic Acid in Tissue Engineering, as a Dermal Filler, and in Osteoarthritis Treatment | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Berkland, Cory J. | |
| kusw.kudepartment | Pharmaceutical Chemistry | en_US |
| kusw.kudepartment | Chemical and Petroleum Engineering | en_US |
| kusw.oanotes | Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF:cross author cannot archive publisher's version/PDF
General Conditions: Authors pre-print on any website, including arXiv and RePEC Author's post-print on author's personal website immediately Author's post-print on open access repository after an embargo period of between 12 months and 48 months Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months Author's post-print may be used to update arXiv and RepEC Publisher's version/PDF cannot be used Must link to publisher version with DOI Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License | en_US |
| dc.identifier.doi | 10.1016/j.actbio.2013.03.005 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC3669638 | en_US |
| dc.rights.accessrights | openAccess | |
