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dc.contributor.authorHanson, Paul R.
dc.contributor.authorChegondi, Rambabu
dc.contributor.authorNguyen, John
dc.contributor.authorThomas, Christopher Daniel
dc.contributor.authorWaetzig, Joshua David
dc.contributor.authorWhitehead, Alan
dc.date.accessioned2017-04-18T15:42:57Z
dc.date.available2017-04-18T15:42:57Z
dc.date.issued2011-06-03
dc.identifier.citationHanson, P. R., Chegondi, R., Nguyen, J., Thomas, C. D., Waetzig, J. D., & Whitehead, A. (2011). Total Synthesis of Dolabelide C: A Phosphate-Mediated Approach. The Journal of Organic Chemistry, 76(11), 4358–4370. http://doi.org/10.1021/jo2003506en_US
dc.identifier.urihttp://hdl.handle.net/1808/23726
dc.description.abstractThe first synthesis of dolabelide C (1), a cytotoxic marine macrolide, is reported utilizing a phosphate tether-mediated approach. Bicyclic phosphates (S,S,SP)-5 and (R,R,RP)-5 serve as the central building blocks for the construction of two major 1,3-anti-diol subunits in 1 through selective cleavage pathways, regioselective olefin reduction and cross-metathesis. Overall, phosphate-mediated processes provided copious amounts of both major subunits allowing for a detailed RCM macrocyclization study to the 24-membered macrolactone 1.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo2003506.en_US
dc.titleTotal Synthesis of Dolabelide C: A Phosphate-Mediated Approachen_US
dc.typeArticleen_US
kusw.kuauthorHanson, Paul R.
kusw.kuauthorChegondi, Rambabu
kusw.kuauthorNguyen, John
kusw.kuauthorThomas, Christopher D.
kusw.kuauthorWaetzig, Joshua D.
kusw.kuauthorWhitehead, Alan
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1021/jo2003506en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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