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dc.contributor.authorChegondi, Rambabu
dc.contributor.authorTan, Mary M. L.
dc.contributor.authorHanson, Paul R.
dc.date.accessioned2017-04-12T18:23:20Z
dc.date.available2017-04-12T18:23:20Z
dc.date.issued2011-05-20
dc.identifier.citationChegondi, R., Tan, M. M. L., & Hanson, P. R. (2011). Phosphate Tether-Mediated Approach to the Formal Total Synthesis of (-)-Salicylihalamides A and B. The Journal of Organic Chemistry, 76(10), 3909–3916. http://doi.org/10.1021/jo200337ven_US
dc.identifier.urihttp://hdl.handle.net/1808/23642
dc.description.abstractA concise formal synthesis of the cytotoxic macrolides (-)-salicylihalamides A and B is reported. Key features of the synthetic strategy include a chemoselective hydroboration, highly regio- and diastereoselective methyl cuprate addition, Pd-catalyzed formate reduction, and an E-selective ring-closing metathesis to construct the 12-membered macrocycle subunit. Overall, two routes have been developed from a readily prepared bicyclic phosphate (4-steps), a 13-step route and a more efficient 9-step sequence relying on regioselective esterification of a key diol.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo200337v.en_US
dc.titlePhosphate Tether-Mediated Approach to the Formal Total Synthesis of (-)-Salicylihalamides A and Ben_US
dc.typeArticleen_US
kusw.kuauthorChegondi, Rambabu
kusw.kuauthorTan, Mary M. L.
kusw.kuauthorHanson, Paul R.
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1021/jo200337ven_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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