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Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)

dc.contributor.authorUllah, Farman
dc.contributor.authorZang, Qin
dc.contributor.authorJaved, Salim
dc.contributor.authorZhou, Aihua
dc.contributor.authorKnudtson, Christopher Anton
dc.contributor.authorBi, Danse
dc.contributor.authorHanson, Paul R.
dc.contributor.authorOrgan, Michael G.
dc.date.accessioned2017-04-05T20:08:48Z
dc.date.available2017-04-05T20:08:48Z
dc.date.issued2012-12
dc.identifier.citationUllah, Farman et al. “Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double Aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).” Journal of flow chemistry 2.4 (2012): 10.1556/JFC–D–12–00015. PMC. Web. 5 Apr. 2017.en_US
dc.identifier.urihttp://hdl.handle.net/1808/23579
dc.description.abstractA microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael addition strategy is reported. The optimized protocol in MACOS was utilized for scale-out and further extended for library production using a multicapillary flow reactor. A 50-member library of 1,2,5-thiadiazepane 1,1-dioxides was prepared on a 100- to 300-mg scale with overall yields between 50 and 80% and over 90 % purity determined by proton nuclear magnetic resonance (1H-NMR) spectroscopy.en_US
dc.publisherAkadémiai Kiadóen_US
dc.subjectDouble aza-Michaelen_US
dc.subjectMACOSen_US
dc.subject1, 2, 5-thiadiazepane 1en_US
dc.subject1-dioxide libraryen_US
dc.subjectSultamsen_US
dc.titleMulticapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)en_US
dc.typeArticleen_US
kusw.kuauthorHanson, Paul R.
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1556/JFC-D-12-00015en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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