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dc.contributor.authorUllah, Farman
dc.contributor.authorZang, Qin
dc.contributor.authorJaved, Salim
dc.contributor.authorZhou, Aihua
dc.contributor.authorKnudtson, Christopher Anton
dc.contributor.authorBi, Danse
dc.contributor.authorHanson, Paul R.
dc.contributor.authorOrgan, Michael G.
dc.date.accessioned2017-04-05T20:08:48Z
dc.date.available2017-04-05T20:08:48Z
dc.date.issued2012-12
dc.identifier.citationUllah, Farman et al. “Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double Aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).” Journal of flow chemistry 2.4 (2012): 10.1556/JFC–D–12–00015. PMC. Web. 5 Apr. 2017.en_US
dc.identifier.urihttp://hdl.handle.net/1808/23579
dc.description.abstractA microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael addition strategy is reported. The optimized protocol in MACOS was utilized for scale-out and further extended for library production using a multicapillary flow reactor. A 50-member library of 1,2,5-thiadiazepane 1,1-dioxides was prepared on a 100- to 300-mg scale with overall yields between 50 and 80% and over 90 % purity determined by proton nuclear magnetic resonance (1H-NMR) spectroscopy.en_US
dc.publisherAkadémiai Kiadóen_US
dc.subjectDouble aza-Michaelen_US
dc.subjectMACOSen_US
dc.subject1, 2, 5-thiadiazepane 1en_US
dc.subject1-dioxide libraryen_US
dc.subjectSultamsen_US
dc.titleMulticapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)en_US
dc.typeArticleen_US
kusw.kuauthorHanson, Paul R.
kusw.kudepartmentChemistryen_US
kusw.oanotesPer SHERPA/RoMEO 4/5/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions: Authors own final version only can be archived Publisher's version/PDF cannot be used On author's personal website or institutional repository or any repository mandated by Author's funding body Published source must be acknowledged Must state that the file is not the final published version of the paper Must link to publisher version(http://dx.doi.org/[DOI of the Article without brackets]) Articles in some journals can be made Open Access on payment of additional chargeen_US
dc.identifier.doi10.1556/JFC-D-12-00015en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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