Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)

Ullah, Farman; Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Christopher Anton; Bi, Danse; Hanson, Paul R.; Organ, Michael G.

dc.contributor.author	Ullah, Farman
dc.contributor.author	Zang, Qin
dc.contributor.author	Javed, Salim
dc.contributor.author	Zhou, Aihua
dc.contributor.author	Knudtson, Christopher Anton
dc.contributor.author	Bi, Danse
dc.contributor.author	Hanson, Paul R.
dc.contributor.author	Organ, Michael G.
dc.date.accessioned	2017-04-05T20:08:48Z
dc.date.available	2017-04-05T20:08:48Z
dc.date.issued	2012-12
dc.identifier.citation	Ullah, Farman et al. “Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double Aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).” Journal of flow chemistry 2.4 (2012): 10.1556/JFC–D–12–00015. PMC. Web. 5 Apr. 2017.	en_US
dc.identifier.uri	http://hdl.handle.net/1808/23579
dc.description.abstract	A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of functionalized 1,2,5-thiadiazepane 1,1-dioxide library, utilizing a one-pot elimination and inter-/intramolecular double aza-Michael addition strategy is reported. The optimized protocol in MACOS was utilized for scale-out and further extended for library production using a multicapillary flow reactor. A 50-member library of 1,2,5-thiadiazepane 1,1-dioxides was prepared on a 100- to 300-mg scale with overall yields between 50 and 80% and over 90 % purity determined by proton nuclear magnetic resonance (1H-NMR) spectroscopy.	en_US
dc.publisher	Akadémiai Kiadó	en_US
dc.subject	Double aza-Michael	en_US
dc.subject	MACOS	en_US
dc.subject	1, 2, 5-thiadiazepane 1	en_US
dc.subject	1-dioxide library	en_US
dc.subject	Sultams	en_US
dc.title	Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)	en_US
dc.type	Article	en_US
kusw.kuauthor	Hanson, Paul R.
kusw.kudepartment	Chemistry	en_US
dc.identifier.doi	10.1556/JFC-D-12-00015	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.rights.accessrights	openAccess

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