| dc.contributor.author | Organ, Michael G. | |
| dc.contributor.author | Hanson, Paul R. | |
| dc.contributor.author | Rolfe, Alan | |
| dc.contributor.author | Samarakoon, Thiwanka Bandara | |
| dc.contributor.author | Ullah, Farman | |
| dc.date.accessioned | 2017-04-05T19:58:33Z | |
| dc.date.available | 2017-04-05T19:58:33Z | |
| dc.date.issued | 2011-08 | |
| dc.identifier.citation | Organ, Michael G. et al. “Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-Out.” Journal of flow chemistry 1.1 (2011): 32–39. PMC. Web. 5 Apr. 2017. | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23578 | |
| dc.description.abstract | The generation of stereochemically-rich benzothiaoxazepine-1,1′-dioxides for enrichment of high-throughput screening collections is reported. Utilizing a microwave-assisted, continuous flow organic synthesis platform (MACOS), scale-out of core benzothiaoxazepine-1,1′-dioxide scaffolds has been achieved on multi-gram scale using an epoxide opening/SNAr cyclization protocol. Diversification of these sultam scaffolds was attained via a microwave-assisted intermolecular SNAr reaction with a variety of amines. Overall, a facile, 2-step protocol generated a collection of benzothiaoxazepine-1,1′-dioxides possessing stereochemical complexity in rapid fashion, where all 8 stereoisomers were accessed from commercially available starting materials. | en_US |
| dc.publisher | Akadémiai Kiadó | en_US |
| dc.subject | MACOS | en_US |
| dc.subject | Sultam | en_US |
| dc.subject | SNAr | en_US |
| dc.subject | DOS | en_US |
| dc.subject | HTS | en_US |
| dc.title | Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Hanson, Paul R. | |
| kusw.kudepartment | Chemistry | en_US |
| kusw.oanotes | Per SHERPA/RoMEO 4/5/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing)
Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing)
Publisher's Version/PDF: cross author cannot archive publisher's version/PDF
General Conditions:
Authors own final version only can be archived
Publisher's version/PDF cannot be used
On author's personal website or institutional repository or any repository mandated by Author's funding body
Published source must be acknowledged
Must state that the file is not the final published version of the paper
Must link to publisher version(http://dx.doi.org/[DOI of the Article without brackets])
Articles in some journals can be made Open Access on payment of additional charge | en_US |
| dc.identifier.doi | 10.1556/jfchem.2011.00008 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess | |
