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dc.contributor.authorOrgan, Michael G.
dc.contributor.authorHanson, Paul R.
dc.contributor.authorRolfe, Alan
dc.contributor.authorSamarakoon, Thiwanka Bandara
dc.contributor.authorUllah, Farman
dc.date.accessioned2017-04-05T19:58:33Z
dc.date.available2017-04-05T19:58:33Z
dc.date.issued2011-08
dc.identifier.citationOrgan, Michael G. et al. “Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-Out.” Journal of flow chemistry 1.1 (2011): 32–39. PMC. Web. 5 Apr. 2017.en_US
dc.identifier.urihttp://hdl.handle.net/1808/23578
dc.description.abstractThe generation of stereochemically-rich benzothiaoxazepine-1,1′-dioxides for enrichment of high-throughput screening collections is reported. Utilizing a microwave-assisted, continuous flow organic synthesis platform (MACOS), scale-out of core benzothiaoxazepine-1,1′-dioxide scaffolds has been achieved on multi-gram scale using an epoxide opening/SNAr cyclization protocol. Diversification of these sultam scaffolds was attained via a microwave-assisted intermolecular SNAr reaction with a variety of amines. Overall, a facile, 2-step protocol generated a collection of benzothiaoxazepine-1,1′-dioxides possessing stereochemical complexity in rapid fashion, where all 8 stereoisomers were accessed from commercially available starting materials.en_US
dc.publisherAkadémiai Kiadóen_US
dc.subjectMACOSen_US
dc.subjectSultamen_US
dc.subjectSNAren_US
dc.subjectDOSen_US
dc.subjectHTSen_US
dc.titleAccessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-outen_US
dc.typeArticleen_US
kusw.kuauthorHanson, Paul R.
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1556/jfchem.2011.00008en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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