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    Hydrating for Resistance to Radicicol

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    Duerfeldt_ACSChemBiol_2009.pdf (373.2Kb)
    Issue Date
    2009-04-17
    Author
    Duerfeldt, Adam S.
    Blagg, Brian S. J.
    Publisher
    ACS Chem Biol.
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    © 2009 American Chemical Society
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    Abstract
    Resistance to Hsp90 inhibition has become an important concern as several clinical trials are currently in progress for the treatment of cancer. A summary of known mechanisms of resistance to Hsp90 inhibitors is provided, including the recent solution of the Humicola fuscoatra Hsp90 structure, the organism responsible for the biosynthesis of radicicol. Through careful analyses of Hsp90 structures, a plausible mechanism for resistance to Hsp90 inhibitors has been obtained by single mutations about the N-terminal ATP-binding site.
    URI
    http://hdl.handle.net/1808/23522
    DOI
    https://doi.org/10.1021/cb9000712
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    • Medicinal Chemistry Scholarly Works [225]
    Citation
    Duerfeldt, A. S., & Blagg, B. S. J. (2009). Hydrating for Resistance to Radicicol. ACS Chemical Biology, 4(4), 245–247. http://doi.org/10.1021/cb9000712

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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