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dc.contributor.authorDuerfeldt, Adam S.
dc.contributor.authorBlagg, Brian S. J.
dc.date.accessioned2017-03-30T17:57:57Z
dc.date.available2017-03-30T17:57:57Z
dc.date.issued2009-04-17
dc.identifier.citationDuerfeldt, A. S., & Blagg, B. S. J. (2009). Hydrating for Resistance to Radicicol. ACS Chemical Biology, 4(4), 245–247. http://doi.org/10.1021/cb9000712en_US
dc.identifier.urihttp://hdl.handle.net/1808/23522
dc.description.abstractResistance to Hsp90 inhibition has become an important concern as several clinical trials are currently in progress for the treatment of cancer. A summary of known mechanisms of resistance to Hsp90 inhibitors is provided, including the recent solution of the Humicola fuscoatra Hsp90 structure, the organism responsible for the biosynthesis of radicicol. Through careful analyses of Hsp90 structures, a plausible mechanism for resistance to Hsp90 inhibitors has been obtained by single mutations about the N-terminal ATP-binding site.en_US
dc.publisherACS Chem Biol.en_US
dc.rights© 2009 American Chemical Societyen_US
dc.titleHydrating for Resistance to Radicicolen_US
dc.typeArticleen_US
kusw.kuauthorDuerfeldt, Adam S.
kusw.kuauthorBlagg, Brian S. J.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1021/cb9000712en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-3130-9890
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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