| dc.contributor.author | Duerfeldt, Adam S. | |
| dc.contributor.author | Blagg, Brian S. J. | |
| dc.date.accessioned | 2017-03-30T17:57:57Z | |
| dc.date.available | 2017-03-30T17:57:57Z | |
| dc.date.issued | 2009-04-17 | |
| dc.identifier.citation | Duerfeldt, A. S., & Blagg, B. S. J. (2009). Hydrating for Resistance to Radicicol. ACS Chemical Biology, 4(4), 245–247. http://doi.org/10.1021/cb9000712 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23522 | |
| dc.description.abstract | Resistance to Hsp90 inhibition has become an important concern as several clinical trials are currently
in progress for the treatment of cancer. A summary of known mechanisms of resistance to Hsp90
inhibitors is provided, including the recent solution of the Humicola fuscoatra Hsp90 structure, the
organism responsible for the biosynthesis of radicicol. Through careful analyses of Hsp90 structures,
a plausible mechanism for resistance to Hsp90 inhibitors has been obtained by single mutations about
the N-terminal ATP-binding site. | en_US |
| dc.publisher | ACS Chem Biol. | en_US |
| dc.rights | © 2009 American Chemical Society | en_US |
| dc.title | Hydrating for Resistance to Radicicol | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Duerfeldt, Adam S. | |
| kusw.kuauthor | Blagg, Brian S. J. | |
| kusw.kudepartment | Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.1021/cb9000712 | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-3130-9890 | |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess | |
