Reaction Pairing: A Diversity-Oriented Synthesis Strategy for the Synthesis of Diverse Benzofused Sultams

Samarakoon, Thiwanka Bandara; Loh, Joanna K.; Rolfe, Alan; Le, Lisa S.; Yoon, Sun Young; Lushington, Gerald H.; Hanson, Paul R.

dc.contributor.author	Samarakoon, Thiwanka Bandara
dc.contributor.author	Loh, Joanna K.
dc.contributor.author	Rolfe, Alan
dc.contributor.author	Le, Lisa S.
dc.contributor.author	Yoon, Sun Young
dc.contributor.author	Lushington, Gerald H.
dc.contributor.author	Hanson, Paul R.
dc.date.accessioned	2017-03-28T15:43:30Z
dc.date.available	2017-03-28T15:43:30Z
dc.date.issued	2011-10-07
dc.identifier.citation	Samarakoon, T. B., Loh, J. K., Rolfe, A., Le, L. S., Yoon, S. Y., Lushington, G. H., & Hanson, P. R. (2011). Reaction Pairing: A Diversity-Oriented Synthesis Strategy for the Synthesis of Diverse Benzofused Sultams. Organic Letters, 13(19), 5148–5151. http://doi.org/10.1021/ol201962n	en_US
dc.identifier.uri	http://hdl.handle.net/1808/23497
dc.description.abstract	A reaction pairing strategy centered on utilization of a reaction triad (sulfonylation, SNAr addition and Mitsunobu alkylation) generating skeletally diverse benzofused tricyclic and bicyclic sultams is reported. Pairing sulfonylation and SNAr reactions yields bridged, tricyclic and bicyclic benzofused sultams. Application of the Mitsunobu reaction in a sulfonylation–Mitsunobu–SNAr pairing allows access to benzo-oxathiazocine-1,1-dioxides, while a simple change in the order of pairing to sulfonylation–SNAr–Mitsunobu affords structurally different, benzofused bridged tricyclic sultams.	en_US
dc.publisher	American Chemical Society	en_US
dc.rights	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol201962n.	en_US
dc.title	Reaction Pairing: A Diversity-Oriented Synthesis Strategy for the Synthesis of Diverse Benzofused Sultams	en_US
dc.type	Article	en_US
kusw.kuauthor	Samarkoon, Thiwanka Bandara
kusw.kuauthor	Loh, Joanna K.
kusw.kuauthor	Rolfe, Alan
kusw.kuauthor	Le, Lisa S.
kusw.kuauthor	Yoon, Young Sun
kusw.kuauthor	Lushington, Gerald H.
kusw.kudepartment	Chemistry	en_US
dc.identifier.doi	10.1021/ol201962n	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.rights.accessrights	openAccess

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