Rapid, Scalable Assembly of Stereochemically Rich, Mono- and Bicyclic Acyl Sultams

Asad, Naeem; Samarakoon, Thiwanka Bandara; Zang, Qin; Loh, Joanna K.; Javed, Salim; Hanson, Paul R.

dc.contributor.author	Asad, Naeem
dc.contributor.author	Samarakoon, Thiwanka Bandara
dc.contributor.author	Zang, Qin
dc.contributor.author	Loh, Joanna K.
dc.contributor.author	Javed, Salim
dc.contributor.author	Hanson, Paul R.
dc.date.accessioned	2017-03-24T18:56:35Z
dc.date.available	2017-03-24T18:56:35Z
dc.date.issued	2014-01-03
dc.identifier.citation	Asad, N., Samarakoon, T. B., Zang, Q., Loh, J. K., Javed, S., & Hanson, P. R. (2014). Rapid, Scalable Assembly of Stereochemically Rich, Mono- and Bicyclic Acyl Sultams. Organic Letters, 16(1), 82–85. http://doi.org/10.1021/ol403070w	en_US
dc.identifier.uri	http://hdl.handle.net/1808/23486
dc.description.abstract	A one-pot, sequential protocol is reported that involves complementary ambiphile pairing (CAP) of a vinyl sulfonamide with a variety of unprotected amino acids via aza-Michael addition and subsequent intramolecular amidation. The method generates diverse, sp3-rich mono- and bicyclic acyl sultams in a highly scalable manner. Modular pairing of stereochemically rich building blocks allows quick access to all possible isomers. Extension to include one-pot, sequential 3-, 4- and 5-multicomponent protocols is also discussed.	en_US
dc.publisher	American Chemical Society	en_US
dc.rights	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol403070w.	en_US
dc.title	Rapid, Scalable Assembly of Stereochemically Rich, Mono- and Bicyclic Acyl Sultams	en_US
dc.type	Article	en_US
kusw.kuauthor	Asad, Naeem
kusw.kuauthor	Samarakoon, Thiwanka B.
kusw.kuauthor	Zang, Qin
kusw.kuauthor	Loh, Joanna K.
kusw.kuauthor	Javed, Salim
kusw.kuauthor	Hanson, Paul R.
kusw.kudepartment	Chemistry	en_US
dc.identifier.doi	10.1021/ol403070w	en_US
dc.identifier.orcid	https://orcid.org/0000-0001-6871-5270
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.rights.accessrights	openAccess

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