Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways

Abstract

Due to their susceptibility towards redox modification, protein thiols represent primary targets for the modulation of protein activity, conformation and oligomerization. Until fairly recently, such modifications were considered “damage” as a result of oxidative stress, before researchers recognized their physiological importance for biologic signaling. This paradigm shift, and the associated necessity to accurately characterize and quantify the various pathways of thiol redox modifications not only for specific proteins, but also within the cellular environment, has enticed researchers to take a close look at the impact of environment and molecular (protein) structure on these reactions. This Special Issue on Redox Biology of Thiols in Signaling Pathways is the result of a workshop organized at the 2013 Annual Meeting of the Society for Free Radical Biology and Medicine in San Antonio, Texas, summarizing the contributions from many of the presenters. It will provide a stimulating synopsis on what is known, and what is not known, about the reaction mechanisms which underlie the role of thiols and oxidative processes in signaling pathways.