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An Efficient, Modular Approach for the Synthesis of (+)-Strictifolione and a Related Natural Product
dc.contributor.author | Jayasinghe, Susanthi | |
dc.contributor.author | Venukadasula, Phanindra K. M. | |
dc.contributor.author | Hanson, Paul R. | |
dc.date.accessioned | 2017-03-08T19:43:52Z | |
dc.date.available | 2017-03-08T19:43:52Z | |
dc.date.issued | 2014-01-03 | |
dc.identifier.citation | Jayasinghe, S., Venukadasula, P. K. M., & Hanson, P. R. (2014). An Efficient, Modular Approach for the Synthesis of (+)-Strictifolione and a Related Natural Product. Organic Letters, 16(1), 122–125. http://doi.org/10.1021/ol403110p | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23362 | |
dc.description.abstract | An efficient, library amenable, “pot economical” total synthesis of (+)-strictifolione and the related natural product, (6R)-6[(E,4R,6R)-4,6-dihydroxy-10-phenyl-1-decenyl]-5,6-dihydro-2H-2-pyrone are reported. This modular approach takes advantage of two consecutive phosphate tether-mediated, one-pot, sequential protocols, followed by a final cross metathesis to deliver both antifungal natural products in a three-pot process from the respective enantiomeric (R,R)- and (S,S)-trienes with minimal purification. A salient feature of this route is that additional protecting groups are not required as a result of the orthogonal protecting- and leaving-group properties innate to phosphate triesters. | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol403110p | en_US |
dc.title | An Efficient, Modular Approach for the Synthesis of (+)-Strictifolione and a Related Natural Product | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Jayasinghe, Susanthi | |
kusw.kuauthor | Venukadasula, Phanindra K. M. | |
kusw.kuauthor | Hanson, Paul R. | |
kusw.kudepartment | Chemistry | en_US |
dc.identifier.doi | 10.1021/ol403110p | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |