ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
A Concise, Phosphate-Mediated Approach to the Total Synthesis of (−)-Tetrahydrolipstatin
| dc.contributor.author | Venukadasula, Phanindra K. M. | |
| dc.contributor.author | Chegondi, Rambabu | |
| dc.contributor.author | Maitra, Soma | |
| dc.contributor.author | Hanson, Paul R. | |
| dc.date.accessioned | 2017-03-08T19:08:10Z | |
| dc.date.available | 2017-03-08T19:08:10Z | |
| dc.date.issued | 2010-04 | |
| dc.identifier.citation | Venukadasula, P. K. M., Chegondi, R., Maitra, S., & Hanson, P. R. (2010). A Concise, Phosphate-Mediated Approach to the Total Synthesis of (−)-Tetrahydrolipstatin. Organic Letters, 12(7), 1556–1559. http://doi.org/10.1021/ol1002913 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23359 | |
| dc.description.abstract | An efficient synthesis of (−)-tetrahydrolipstatin (THL) is reported. This method takes advantage of a phosphate tether-mediated, one-pot, sequential RCM/CM/hydrogenation protocol to deliver THL in 8 total steps from a readily prepared (S,S)-triene. The strategy incorporates selective cross metathesis, regio-selective hydrogenation, regio- and diastereoselective cuprate addition and Mitsunobu inversion for installation of the C5 formamide ester subunit. | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol1002913 | en_US |
| dc.title | A Concise, Phosphate-Mediated Approach to the Total Synthesis of (−)-Tetrahydrolipstatin | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Venukadasula, Phanindra K. M. | |
| kusw.kuauthor | Chegondi, Rambabu | |
| kusw.kuauthor | Maitra, Soma | |
| kusw.kuauthor | Hanson, Paul R. | |
| kusw.kudepartment | Chemistry | en_US |
| dc.identifier.doi | 10.1021/ol1002913 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess |
