A Concise, Phosphate-Mediated Approach to the Total Synthesis of (−)-Tetrahydrolipstatin

Venukadasula, Phanindra K. M.; Chegondi, Rambabu; Maitra, Soma; Hanson, Paul R.

dc.contributor.author	Venukadasula, Phanindra K. M.
dc.contributor.author	Chegondi, Rambabu
dc.contributor.author	Maitra, Soma
dc.contributor.author	Hanson, Paul R.
dc.date.accessioned	2017-03-08T19:08:10Z
dc.date.available	2017-03-08T19:08:10Z
dc.date.issued	2010-04
dc.identifier.citation	Venukadasula, P. K. M., Chegondi, R., Maitra, S., & Hanson, P. R. (2010). A Concise, Phosphate-Mediated Approach to the Total Synthesis of (−)-Tetrahydrolipstatin. Organic Letters, 12(7), 1556–1559. http://doi.org/10.1021/ol1002913	en_US
dc.identifier.uri	http://hdl.handle.net/1808/23359
dc.description.abstract	An efficient synthesis of (−)-tetrahydrolipstatin (THL) is reported. This method takes advantage of a phosphate tether-mediated, one-pot, sequential RCM/CM/hydrogenation protocol to deliver THL in 8 total steps from a readily prepared (S,S)-triene. The strategy incorporates selective cross metathesis, regio-selective hydrogenation, regio- and diastereoselective cuprate addition and Mitsunobu inversion for installation of the C5 formamide ester subunit.	en_US
dc.publisher	American Chemical Society	en_US
dc.rights	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol1002913	en_US
dc.title	A Concise, Phosphate-Mediated Approach to the Total Synthesis of (−)-Tetrahydrolipstatin	en_US
dc.type	Article	en_US
kusw.kuauthor	Venukadasula, Phanindra K. M.
kusw.kuauthor	Chegondi, Rambabu
kusw.kuauthor	Maitra, Soma
kusw.kuauthor	Hanson, Paul R.
kusw.kudepartment	Chemistry	en_US
dc.identifier.doi	10.1021/ol1002913	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.rights.accessrights	openAccess

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