dc.date.accessioned | 2017-02-27T22:28:40Z | |
dc.date.available | 2017-02-27T22:28:40Z | |
dc.date.issued | 2012-10-01 | |
dc.identifier.citation | Zhang, Z., J. Yan, Y. Chang, S. Shidu Yan, and H. Shi. "Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases." Current Medicinal Chemistry 18.28 (2011): 4335-343. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23280 | |
dc.description.abstract | Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor responsible for cellular and tissue adaption to low oxygen tension. HIF-1, a heterodimer consisting of a constitutively expressed β subunit and an oxygen-regulated α subunit, regulates a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The activity of HIF-1 is controlled by post-translational modifications on different amino acid residues of its subunits, mainly the alpha subunit. Besides in ischemic stroke (see review [1]), emerging evidence has revealed that HIF-1 activity and expression of its down-stream genes, such as vascular endothelial growth factor and erythropoietin, are altered in a range of neurodegenerative diseases. At the same time, experimental and clinical evidence has demonstrated that regulating HIF-1 might ameliorate the cellular and tissue damage in the neurodegenerative diseases. These new findings suggest HIF-1 as a potential medicinal target for the neurodegenerative diseases. This review focuses on HIF-1α protein modifications and HIF-1’s potential neuroprotective roles in Alzheimer’s (AD), Parkinson’s (PD), Huntington’s diseases (HD), and amyotrophic lateral sclerosis (ALS). | en_US |
dc.publisher | Bentham Science Publishers | en_US |
dc.subject | AD | en_US |
dc.subject | ALS | en_US |
dc.subject | EPO | en_US |
dc.subject | HD | en_US |
dc.subject | HIF-1 | en_US |
dc.subject | VEGF | en_US |
dc.subject | Protein modification | en_US |
dc.subject | Prolyl hydroxylase inhibitor | en_US |
dc.subject | Iron chelator | en_US |
dc.subject | 2-oxoglutarate analogues | en_US |
dc.subject | Cobalt | en_US |
dc.subject | Neurodegenerative diseases | en_US |
dc.title | Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Yan, Shirley Shidu | |
kusw.kudepartment | Pharmacology & Toxicology | en_US |
dc.identifier.doi | 10.2174/092986711797200426 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | |