Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases

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Issue Date
2012-10-01Publisher
Bentham Science Publishers
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
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Show full item recordAbstract
Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor responsible for cellular and tissue adaption to low oxygen tension. HIF-1, a heterodimer consisting of a constitutively expressed β subunit and an oxygen-regulated α subunit, regulates a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The activity of HIF-1 is controlled by post-translational modifications on different amino acid residues of its subunits, mainly the alpha subunit. Besides in ischemic stroke (see review [1]), emerging evidence has revealed that HIF-1 activity and expression of its down-stream genes, such as vascular endothelial growth factor and erythropoietin, are altered in a range of neurodegenerative diseases. At the same time, experimental and clinical evidence has demonstrated that regulating HIF-1 might ameliorate the cellular and tissue damage in the neurodegenerative diseases. These new findings suggest HIF-1 as a potential medicinal target for the neurodegenerative diseases. This review focuses on HIF-1α protein modifications and HIF-1’s potential neuroprotective roles in Alzheimer’s (AD), Parkinson’s (PD), Huntington’s diseases (HD), and amyotrophic lateral sclerosis (ALS).
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- Pharmacy Scholarly Works [293]
Citation
Zhang, Z., J. Yan, Y. Chang, S. Shidu Yan, and H. Shi. "Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases." Current Medicinal Chemistry 18.28 (2011): 4335-343.
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