dc.contributor.author | Huang, Tianwen | |
dc.contributor.author | Fang, Fang | |
dc.contributor.author | Chen, Limin | |
dc.contributor.author | Zhu, Yuangui | |
dc.contributor.author | Zhang, Jing | |
dc.contributor.author | Chen, Xiaochun | |
dc.contributor.author | Yan, Shirley ShiDu | |
dc.date.accessioned | 2017-02-27T22:14:48Z | |
dc.date.available | 2017-02-27T22:14:48Z | |
dc.date.issued | 2013-03-01 | |
dc.identifier.citation | Huang, Tianwen, Fang Fang, Limin Chen, Yuangui Zhu, Jing Zhang, Xiaochun Chen, and Shirley Shidu Yan. "Ginsenoside Rg1 Attenuates Oligomeric Aβ1-42-Induced Mitochondrial Dysfunction." Current Alzheimer Research 9.3 (2012): 388-95. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23277 | |
dc.description.abstract | Mitochondrial dysfunction is one of the major pathological changes seen in Alzheimer's disease (AD). Amyloid beta-peptide (Aβ), a neurotoxic peptide, accumulates in the brain of AD subjects and mediates mitochondrial and neuronal stress. Therefore, protecting mitochondrion from Aβ-induced toxicity holds potential benefits for halting and treating and perhaps preventing AD. Here, we report that administration of ginsenoside Rg1, a known neuroprotective drug, to primary cultured cortical neurons, rescues Aβ-mediated mitochondrial dysfunction as shown by increases in mitochondrial membrane potential, ATP levels, activity of cytochrome c oxidase (a key enzyme associated with mitochondrial respiratory function), and decreases in cytochrome c release. The protective effects of Rg1 on mitochondrial dysfunction correlate to neuronal injury in the presence of Aβ. This finding suggests that ginsenoside Rg1 may attenuate Aβ-induced neuronal death through the suppression of intracellular mitochondrial oxidative stress and may rescue neurons in AD. | en_US |
dc.publisher | Bentham Science Publishers | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Oligmeric beta-amyloid peptide 1-42 | en_US |
dc.subject | Mitochondria | en_US |
dc.subject | Ginsenoside Rg1 | en_US |
dc.title | Ginsenoside Rg1 Attenuates Oligomeric Aβ1-42-Induced Mitochondrial Dysfunction | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Yan, Shirley Shidu | |
kusw.kudepartment | Pharmacology & Toxicology | en_US |
dc.identifier.doi | 10.2174/156720512800107636 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | |