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    Ginsenoside Rg1 Attenuates Oligomeric Aβ1-42-Induced Mitochondrial Dysfunction

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    Issue Date
    2013-03-01
    Author
    Huang, Tianwen
    Fang, Fang
    Chen, Limin
    Zhu, Yuangui
    Zhang, Jing
    Chen, Xiaochun
    Yan, Shirley ShiDu
    Publisher
    Bentham Science Publishers
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Mitochondrial dysfunction is one of the major pathological changes seen in Alzheimer's disease (AD). Amyloid beta-peptide (Aβ), a neurotoxic peptide, accumulates in the brain of AD subjects and mediates mitochondrial and neuronal stress. Therefore, protecting mitochondrion from Aβ-induced toxicity holds potential benefits for halting and treating and perhaps preventing AD. Here, we report that administration of ginsenoside Rg1, a known neuroprotective drug, to primary cultured cortical neurons, rescues Aβ-mediated mitochondrial dysfunction as shown by increases in mitochondrial membrane potential, ATP levels, activity of cytochrome c oxidase (a key enzyme associated with mitochondrial respiratory function), and decreases in cytochrome c release. The protective effects of Rg1 on mitochondrial dysfunction correlate to neuronal injury in the presence of Aβ. This finding suggests that ginsenoside Rg1 may attenuate Aβ-induced neuronal death through the suppression of intracellular mitochondrial oxidative stress and may rescue neurons in AD.
    URI
    http://hdl.handle.net/1808/23277
    DOI
    https://doi.org/10.2174/156720512800107636
    Collections
    • Pharmacy Scholarly Works [261]
    Citation
    Huang, Tianwen, Fang Fang, Limin Chen, Yuangui Zhu, Jing Zhang, Xiaochun Chen, and Shirley Shidu Yan. "Ginsenoside Rg1 Attenuates Oligomeric Aβ1-42-Induced Mitochondrial Dysfunction." Current Alzheimer Research 9.3 (2012): 388-95.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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