Show simple item record

dc.contributor.authorRao, Deepa A.
dc.contributor.authorForrest, M. Laird
dc.contributor.authorAlani, Adam W.G.
dc.contributor.authorKwon, Glen S.
dc.contributor.authorRobinson, Joseph R.
dc.date.accessioned2017-02-23T20:42:29Z
dc.date.available2017-02-23T20:42:29Z
dc.date.issued2010-04
dc.identifier.citationRAO, D. A., FORREST, M. L., ALANI, A. W. G., KWON, G. S., & ROBINSON, J. R. (2010). Biodegradable PLGA Based Nanoparticles for Sustained Regional Lymphatic Drug Delivery. Journal of Pharmaceutical Sciences, 99(4), 2018–2031. http://doi.org/10.1002/jps.21970en_US
dc.identifier.urihttp://hdl.handle.net/1808/23241
dc.description.abstractThe purpose of this work is to evaluate biodegradable drug carriers with defined size, hydrophobicity, and surface charge density for preferential lymphatic uptake and retention for sustained regional drug delivery. PLGA–PMA:PLA-PEG (PP) nanoparticles of defined size and relative hydrophobicity were prepared by nanoprecipitation method. These were compared with PS particles of similar sizes and higher hydrophobicity. PLGA–PMA:PLGA-COOH (PC) particles at 80:20, 50:50, and 20:80 ratios were prepared by nanoprecipitation for the charge study. Particle size and zeta potential were characterized by dynamic light scattering and laser doppler anemometry, respectively. Particles were administered in vivo to rats subcutaneously. Systemic and lymph node uptake was evaluated by marker recovery. Lymphatic uptake and node retention of PP nanoparticles was shown to be inversely related to size. Lymphatic uptake and node retention of PP particles, as compared to PS particles, was shown to be inversely related to hydrophobicity. Lastly, lymphatic uptake and node retention of PC nanoparticles were directly related to the anionic charge on the particles. In vivo lymphatic uptake and retention in a rat model indicates that the 50 nm PP particles are ideal for sustained regional delivery into the lymphatics for prevention/treatment of oligometastases.en_US
dc.publisherElsevieren_US
dc.rights© 2009 Wiley-Liss, Inc. and the American Pharmacists Associationen_US
dc.subjectPLGAen_US
dc.subjectLymphatic transporten_US
dc.subjectNanoparticlesen_US
dc.subjectBiocompatibilityen_US
dc.subjectDistributionen_US
dc.titleBiodegradable PLGA Based Nanoparticles for Sustained Regional Lymphatic Drug Deliveryen_US
dc.typeArticleen_US
kusw.kuauthorForrest, M. Laird
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1002/jps.21970en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record