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dc.contributor.authorCohen, Stephanie M.
dc.contributor.authorMukerji, Ridhwi
dc.contributor.authorCai, Shuang
dc.contributor.authorDamjanov, Ivan
dc.contributor.authorForrest, M. Laird
dc.contributor.authorCohen, Mark S.
dc.date.accessioned2017-02-23T17:58:46Z
dc.date.available2017-02-23T17:58:46Z
dc.date.issued2011-10-08
dc.identifier.citationCohen, S. M., Mukerji, R., Cai, S., Damjanov, I., Forrest, M. L., & Cohen, M. S. (2011). Subcutaneous Delivery of Nanoconjugated Doxorubicin and Cisplatin for Locally Advanced Breast Cancer Demonstrates Improved Efficacy and Decreased Toxicity at Lower Doses Than Standard Systemic Combination Therapy In Vivo. American Journal of Surgery, 202(6), 646–653. http://doi.org/10.1016/j.amjsurg.2011.06.027en_US
dc.identifier.urihttp://hdl.handle.net/1808/23237
dc.description.abstractBackground—Combination cytotoxic agents in breast cancer carry dose-limiting toxicities. We hypothesize that nanocarrier-conjugated doxorubicin and cisplatin will have improved tumor efficacy with decreased systemic toxicity over standard drugs, even at lower doses.

Methods—Female Nu/Nu mice were injected in the breast with human MDA-MB-468LN cells and treated with either standard or nanocarrier-conjugated combination therapy (doxorubicin +cisplatin) at 50% or 75% MTD, and monitored for efficacy and toxicity over 12-weeks.

Results—Efficacy results for mice treated with HA-conjugated doxorubicin/cisplatin at 50% MTD include:[complete responses(CR)=5, partial responses(PR)=2, and stable disease(SD)=1]and for HA-conjugated dox/cis at 75% MTD:[CR=7,PR=1; all CR’s confirmed histologically]. In comparison, mice given standard dox/cis(50% MTD)demonstrated:[progressive disease(PD)=6, SD=1, and PR=1] and for standard dox/cis(75% MTD):[PD=5,SD=3; p<0.0001 on multivariate ANOVA]. At 75% MTD, standard drug-treated mice had significant weight loss compared to nanocarrier drug-treated mice(p<0.001).

Conclusion—Subcutaneous nanocarrier-delivery of doxorubicin and cisplatin demonstrated significantly improved efficacy with decreased toxicity compared to standard agent combination therapy at all doses tested achieving complete pathologic tumor response.
en_US
dc.publisherElsevieren_US
dc.rightsCopyright © 2011 Elsevier Inc. All rights reserved.en_US
dc.subjectNanocarriersen_US
dc.subjectDrug-deliveryen_US
dc.subjectCombination chemotherapyen_US
dc.subjectHyaluronic aciden_US
dc.subjectBreast canceren_US
dc.subjectLocoregional therapyen_US
dc.titleSubcutaneous Delivery of Nanoconjugated Doxorubicin and Cisplatin for Locally Advanced Breast Cancer Demonstrates Improved Efficacy and Decreased Toxicity at Lower Doses Than Standard Systemic Combination Therapy In Vivoen_US
dc.typeArticleen_US
kusw.kuauthorCai, Shuang
kusw.kuauthorForrest, M. Laird
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1016/j.amjsurg.2011.06.027en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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