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Fluorescent Mimics of Cholesterol that Rapidly Bind Surfaces of Living Mammalian Cells
| dc.contributor.author | Hymel, David | |
| dc.contributor.author | Cai, Sutang | |
| dc.contributor.author | Henkhaus, Rebecca S. | |
| dc.contributor.author | Perera, Chamani | |
| dc.contributor.author | Peterson, Blake R. | |
| dc.date.accessioned | 2017-02-22T20:46:12Z | |
| dc.date.available | 2017-02-22T20:46:12Z | |
| dc.date.issued | 2016-10-07 | |
| dc.identifier.citation | Hymel, David, Sutang Cai, Qi Sun, Rebecca S. Henkhaus, Chamani Perera, and Blake R. Peterson. "Fluorescent Mimics of Cholesterol That Rapidly Bind Surfaces of Living Mammalian Cells." Chem. Commun. 51.78 (2015): 14624-4627. | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23221 | |
| dc.description.abstract | Mammalian cells acquire cholesterol, a critical membrane constituent, through multiple mechanisms. We synthesized mimics of cholesterol, fluorescent N-alkyl-3β-cholesterylamine-glutamic acids, that are rapidly incorporated into cellular plasma membranes compared with analogous cholesteryl amides, ethers, esters, carbamates, and a sitosterol analogue. This process was inhibited by ezetimibe, indicating a receptor-mediated uptake pathway. | en_US |
| dc.publisher | Royal Society of Chemistry | en_US |
| dc.title | Fluorescent Mimics of Cholesterol that Rapidly Bind Surfaces of Living Mammalian Cells | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Peterson, Blake R. | |
| kusw.kudepartment | Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.1039/c5cc06325f | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess |
