Fluorescent Mimics of Cholesterol that Rapidly Bind Surfaces of Living Mammalian Cells

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Issue Date
2016-10-07Author
Hymel, David
Cai, Sutang
Henkhaus, Rebecca S.
Perera, Chamani
Peterson, Blake R.
Publisher
Royal Society of Chemistry
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Metadata
Show full item recordAbstract
Mammalian cells acquire cholesterol, a critical membrane constituent, through multiple mechanisms. We synthesized mimics of cholesterol, fluorescent N-alkyl-3β-cholesterylamine-glutamic acids, that are rapidly incorporated into cellular plasma membranes compared with analogous cholesteryl amides, ethers, esters, carbamates, and a sitosterol analogue. This process was inhibited by ezetimibe, indicating a receptor-mediated uptake pathway.
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Citation
Hymel, David, Sutang Cai, Qi Sun, Rebecca S. Henkhaus, Chamani Perera, and Blake R. Peterson. "Fluorescent Mimics of Cholesterol That Rapidly Bind Surfaces of Living Mammalian Cells." Chem. Commun. 51.78 (2015): 14624-4627.
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