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Reagent based DOS: A "Click, Click, Cyclize" strategy to probe chemical space

dc.contributor.authorRolfe, Alan
dc.contributor.authorLushington, Gerald H.
dc.contributor.authorHanson, Paul R.
dc.date.accessioned2017-02-21T18:41:13Z
dc.date.available2017-02-21T18:41:13Z
dc.date.issued2010-05-07
dc.identifier.citationRolfe, A., Lushington, G. H., & Hanson, P. R. (2010). Reagent based DOS: A “Click, Click, Cyclize” strategy to probe chemical space. Organic & Biomolecular Chemistry, 8(9), 2198–2203. http://doi.org/10.1039/b927161aen_US
dc.identifier.urihttp://hdl.handle.net/1808/23215
dc.description.abstractThe synthesis of small organic molecules as probes for discovering new therapeutic agents has been an important aspect of chemical-biology. Herein we report a reagent-based, diversity-oriented synthetic (DOS) strategy to probe chemical and biological space via a “Click, Click, Cyclize” protocol. In this DOS approach, three sulfonamide linchpins underwent cyclization protocols with a variety of reagents to yield a collection of structurally diverse S-heterocycles. In silico analysis is utilized to evaluate the diversity of the compound collection against chemical space (PC analysis), shape space (PMI) and polar surface area (PSA) calculations.en_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleReagent based DOS: A "Click, Click, Cyclize" strategy to probe chemical spaceen_US
dc.typeArticleen_US
kusw.kuauthorRolfe, Alan
kusw.kuauthorLushington, Gerald H.
kusw.kuauthorHanson, Paul R.
kusw.kudepartmentChemistryen_US
dc.identifier.doi10.1039/b927161aen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.