ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Reagent based DOS: A "Click, Click, Cyclize" strategy to probe chemical space
dc.contributor.author | Rolfe, Alan | |
dc.contributor.author | Lushington, Gerald H. | |
dc.contributor.author | Hanson, Paul R. | |
dc.date.accessioned | 2017-02-21T18:41:13Z | |
dc.date.available | 2017-02-21T18:41:13Z | |
dc.date.issued | 2010-05-07 | |
dc.identifier.citation | Rolfe, A., Lushington, G. H., & Hanson, P. R. (2010). Reagent based DOS: A “Click, Click, Cyclize” strategy to probe chemical space. Organic & Biomolecular Chemistry, 8(9), 2198–2203. http://doi.org/10.1039/b927161a | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23215 | |
dc.description.abstract | The synthesis of small organic molecules as probes for discovering new therapeutic agents has been an important aspect of chemical-biology. Herein we report a reagent-based, diversity-oriented synthetic (DOS) strategy to probe chemical and biological space via a “Click, Click, Cyclize” protocol. In this DOS approach, three sulfonamide linchpins underwent cyclization protocols with a variety of reagents to yield a collection of structurally diverse S-heterocycles. In silico analysis is utilized to evaluate the diversity of the compound collection against chemical space (PC analysis), shape space (PMI) and polar surface area (PSA) calculations. | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Reagent based DOS: A "Click, Click, Cyclize" strategy to probe chemical space | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Rolfe, Alan | |
kusw.kuauthor | Lushington, Gerald H. | |
kusw.kuauthor | Hanson, Paul R. | |
kusw.kudepartment | Chemistry | en_US |
dc.identifier.doi | 10.1039/b927161a | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.