Effects of nanomaterial physicochemical properties on in vivo toxicity
dc.contributor.author | Aillon, Kristin L. | |
dc.contributor.author | Xie, Yumei | |
dc.contributor.author | El-Gendy, Nashwa | |
dc.contributor.author | Berkland, Cory J. | |
dc.contributor.author | Forrest, M. Laird | |
dc.date.accessioned | 2017-01-12T18:04:41Z | |
dc.date.available | 2017-01-12T18:04:41Z | |
dc.date.issued | 2010-06-21 | |
dc.identifier.citation | Aillon, Kristin L., Yumei Xie, Nashwa El-Gendy, Cory J. Berkland, and M. Laird Forrest. "Effects of Nanomaterial Physicochemical Properties on in Vivo Toxicity." Advanced Drug Delivery Reviews 61.6 (2009): 457-66. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22607 | |
dc.description.abstract | It is well recognized that physical and chemical properties of materials can alter dramatically at nanoscopic scale, and the growing use of nanotechnologies requires careful assessment of unexpected toxicities and biological interactions. However, most in vivo toxicity concerns focus primarily on pulmonary, oral, and dermal exposure to ultrafine particles. As nanomaterials expand as therapeutics and as diagnostic tools, parenteral administration of engineered nanomaterials should also be recognized as a critical aspect for toxicity consideration. Due to the complex nature of nanomaterials, conflicting studies have led to different views of their safety. Here, the physicochemical properties of four representative nanomaterials (dendrimers, carbon nanotubes, quantum dots, and gold nanoparticles) as it relates to their toxicity after systemic exposure is discussed. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | Nanomaterial | en_US |
dc.subject | Toxicity | en_US |
dc.subject | In vivo | en_US |
dc.subject | Dendrimer | en_US |
dc.subject | Carbon nanotube | en_US |
dc.subject | Quantum dot | en_US |
dc.subject | Gold nanoparticle | en_US |
dc.subject | Analysis | en_US |
dc.title | Effects of nanomaterial physicochemical properties on in vivo toxicity | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Forrest, M. Laird | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.1016/j.addr.2009.03.010 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.