Advances in Lymphatic Imaging and Drug Delivery
dc.contributor.author | Nune, Satish K. | |
dc.contributor.author | Gunda, Padmaja | |
dc.contributor.author | Majeti, Bharat K. | |
dc.contributor.author | Thallapally, Praveen K. | |
dc.contributor.author | Forrest, M. Laird | |
dc.date.accessioned | 2017-01-12T18:00:09Z | |
dc.date.available | 2017-01-12T18:00:09Z | |
dc.date.issued | 2012-09-10 | |
dc.identifier.citation | Nune, Satish K., Padmaja Gunda, Bharat K. Majeti, Praveen K. Thallapally, and M. Laird Forrest. "Advances in Lymphatic Imaging and Drug Delivery." Advanced Drug Delivery Reviews 63.10-11 (2011): 876-85. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22606 | |
dc.description.abstract | Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases will have invaded the lymphatic system as a first step in their progression. Hence, proper evaluation of the disease state of the lymphatics which drain a tumor site is crucial to staging and the formation of a treatment plan. Current lymphatic imaging modalities with visible dyes and radionucleotide tracers offer limited sensitivity and poor resolution; however, newer tools using nanocarriers, quantum dots, and magnetic resonance imaging promise to vastly improve the staging of lymphatic spread without needless biopsies. Concurrent with the improvement of lymphatic imaging agents, has been the development of drug carriers that can localize chemotherapy to the lymphatic system, thus improving the treatment of localized disease while minimizing the exposure of healthy organs to cytotoxic drugs. This review will focus on the use of various nanoparticulate and polymeric systems that have been developed for imaging and drug delivery to the lymph system, how these new devices improve upon current technologies, and where further improvement is needed. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | Drug delivery | en_US |
dc.subject | Polymeric carriers | en_US |
dc.subject | Lymphatic system | en_US |
dc.subject | Sentinel lymph nodes | en_US |
dc.subject | Quantum dots | en_US |
dc.subject | Dendrimers | en_US |
dc.title | Advances in Lymphatic Imaging and Drug Delivery | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Forrest, M. Laird | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.1016/j.addr.2011.05.020 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-2971-0554 | |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.