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Cytotoxic Withanolide Constituents of Physalis longifolia
dc.contributor.author | Zhang, Huaping | |
dc.contributor.author | Samadi, Abbas K. | |
dc.contributor.author | Gallagher, Robert J. | |
dc.contributor.author | Araya, Juan Jose | |
dc.contributor.author | Tong, Xiaoqin | |
dc.contributor.author | Day, Victor W. | |
dc.contributor.author | Cohen, Mark S. | |
dc.contributor.author | Kindscher, Kelly | |
dc.contributor.author | Gollapudi, Rao | |
dc.contributor.author | Timmermann, Barbara N. | |
dc.date.accessioned | 2017-01-11T20:05:04Z | |
dc.date.available | 2017-01-11T20:05:04Z | |
dc.date.issued | 2011-11-08 | |
dc.identifier.citation | Zhang, Huaping, Abbas K. Samadi, Robert J. Gallagher, Juan J. Araya, Xiaoqin Tong, Victor W. Day, Mark S. Cohen, Kelly Kindscher, Rao Gollapudi, and Barbara N. Timmermann. "Cytotoxic Withanolide Constituents OfPhysalis Longifolia." Journal of Natural Products 74.12 (2011): 2532-544. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22581 | |
dc.description.abstract | Fourteen new withanolides, 1–14, named withalongolides A–N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15–22). The structures of compounds 1–14 were elucidated through spectroscopic techniques and chemical methods. In addition, the structures of withanolides 1, 2, 3, and 6 were confirmed by X-ray crystallographic analysis. Using a MTS viability assay, eight withanolides (1, 2, 3, 7, 8, 15, 16, and 19) and four acetylated derivatives (1a, 1b, 2a, and 2b) showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986), melanoma (B16F10 and SKMEL-28), and normal fetal fibroblast (MRC-5) cells with IC50 values in the range between 0.067 and 9.3 μM. | en_US |
dc.publisher | Journal of Natural Products | en_US |
dc.rights | Copyright © 2011 The American Chemical Society and American Society of Pharmacognosy | en_US |
dc.title | Cytotoxic Withanolide Constituents of Physalis longifolia | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Timmerman, Barbara N. | |
kusw.kuauthor | Day, Victor W. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
kusw.kudepartment | MSG-Xray Crystallography Lab | en_US |
dc.identifier.doi | 10.1021/np200635r | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-4525-7291 | |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |