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    Cytotoxic Withanolide Constituents of Physalis longifolia

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    Issue Date
    2011-11-08
    Author
    Zhang, Huaping
    Samadi, Abbas K.
    Gallagher, Robert J.
    Araya, Juan Jose
    Tong, Xiaoqin
    Day, Victor W.
    Cohen, Mark S.
    Kindscher, Kelly
    Gollapudi, Rao
    Timmermann, Barbara N.
    Publisher
    Journal of Natural Products
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Rights
    Copyright © 2011 The American Chemical Society and American Society of Pharmacognosy
    Metadata
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    Abstract
    Fourteen new withanolides, 1–14, named withalongolides A–N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15–22). The structures of compounds 1–14 were elucidated through spectroscopic techniques and chemical methods. In addition, the structures of withanolides 1, 2, 3, and 6 were confirmed by X-ray crystallographic analysis. Using a MTS viability assay, eight withanolides (1, 2, 3, 7, 8, 15, 16, and 19) and four acetylated derivatives (1a, 1b, 2a, and 2b) showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986), melanoma (B16F10 and SKMEL-28), and normal fetal fibroblast (MRC-5) cells with IC50 values in the range between 0.067 and 9.3 μM.
    URI
    http://hdl.handle.net/1808/22581
    DOI
    https://doi.org/10.1021/np200635r
    Collections
    • Medicinal Chemistry Scholarly Works [242]
    Citation
    Zhang, Huaping, Abbas K. Samadi, Robert J. Gallagher, Juan J. Araya, Xiaoqin Tong, Victor W. Day, Mark S. Cohen, Kelly Kindscher, Rao Gollapudi, and Barbara N. Timmermann. "Cytotoxic Withanolide Constituents OfPhysalis Longifolia." Journal of Natural Products 74.12 (2011): 2532-544.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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