Cytotoxic Withanolide Constituents of Physalis longifolia

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Issue Date
2011-11-08Author
Zhang, Huaping
Samadi, Abbas K.
Gallagher, Robert J.
Araya, Juan Jose
Tong, Xiaoqin
Day, Victor W.
Cohen, Mark S.
Kindscher, Kelly
Gollapudi, Rao
Timmermann, Barbara N.
Publisher
Journal of Natural Products
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
Copyright © 2011 The American Chemical Society and American Society of Pharmacognosy
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Show full item recordAbstract
Fourteen new withanolides, 1–14, named withalongolides A–N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15–22). The structures of compounds 1–14 were elucidated through spectroscopic techniques and chemical methods. In addition, the structures of withanolides 1, 2, 3, and 6 were confirmed by X-ray crystallographic analysis. Using a MTS viability assay, eight withanolides (1, 2, 3, 7, 8, 15, 16, and 19) and four acetylated derivatives (1a, 1b, 2a, and 2b) showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986), melanoma (B16F10 and SKMEL-28), and normal fetal fibroblast (MRC-5) cells with IC50 values in the range between 0.067 and 9.3 μM.
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Citation
Zhang, Huaping, Abbas K. Samadi, Robert J. Gallagher, Juan J. Araya, Xiaoqin Tong, Victor W. Day, Mark S. Cohen, Kelly Kindscher, Rao Gollapudi, and Barbara N. Timmermann. "Cytotoxic Withanolide Constituents OfPhysalis Longifolia." Journal of Natural Products 74.12 (2011): 2532-544.
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