Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates

Ambler, Brett R.; Peddi, Santosh; Altman, Ryan A.

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Issue Date

2015-07-15

Author

Ambler, Brett R.

Peddi, Santosh

Altman, Ryan A.

Publisher

Thieme Publishing

Type

Article

Article Version

Scholarly/refereed, author accepted manuscript

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Abstract

The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic Cu for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.

Citation

Altman, Ryan, Brett Ambler, and Santosh Peddi. "Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates." Synthesis 46.14 (2014): 1938-946.

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