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    The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders

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    MosconiW_2015.pdf (870.7Kb)
    Issue Date
    2016-09-01
    Author
    Mosconi, Matthew W.
    Wang, Zheng
    Schmitt, Lauren M.
    Tsai, Peter
    Sweeney, John A.
    Publisher
    Frontiers Media
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Rights
    This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
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    Abstract
    The cerebellum has been repeatedly implicated in gene expression, rodent model and post-mortem studies of autism spectrum disorder (ASD). How cellular and molecular anomalies of the cerebellum relate to clinical manifestations of ASD remains unclear. Separate circuits of the cerebellum control different sensorimotor behaviors, such as maintaining balance, walking, making eye movements, reaching, and grasping. Each of these behaviors has been found to be impaired in ASD, suggesting that multiple distinct circuits of the cerebellum may be involved in the pathogenesis of patients' sensorimotor impairments. We will review evidence that the development of these circuits is disrupted in individuals with ASD and that their study may help elucidate the pathophysiology of sensorimotor deficits and core symptoms of the disorder. Preclinical studies of monogenetic conditions associated with ASD also have identified selective defects of the cerebellum and documented behavioral rescues when the cerebellum is targeted. Based on these findings, we propose that cerebellar circuits may prove to be promising targets for therapeutic development aimed at rescuing sensorimotor and other clinical symptoms of different forms of ASD.
    URI
    http://hdl.handle.net/1808/22160
    DOI
    https://doi.org/10.3389/fnins.2015.00296
    Collections
    • Applied Behavioral Science Scholarly Works [105]
    Citation
    Mosconi, M. W., Wang, Z., Schmitt, L. M., Tsai, P., & Sweeney, J. A. (2015). The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders. Frontiers in Neuroscience, 9. doi:10.3389/fnins.2015.00296

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    KU Libraries
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    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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