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dc.contributor.authorBuckberry, Sam
dc.contributor.authorSpronk, Fleur
dc.contributor.authorWilson, Rebecca L.
dc.contributor.authorLaurence, Jessica A.
dc.contributor.authorBianco-Miotto, Tina
dc.contributor.authorLeemaqz, Shalem
dc.contributor.authorO'Leary, Sean
dc.contributor.authorAnderson, Paul H.
dc.contributor.authorRoberts, Claire T.
dc.date.accessioned2016-12-05T19:03:08Z
dc.date.available2016-12-05T19:03:08Z
dc.date.issued2015
dc.identifier.citationBuckberry, S., Spronk, F., Wilson, R. L., Laurence, J. A., Bianco-Miotto, T., Leemaqz, S., … Roberts, C. T. (2015). The effect of Vdr gene ablation on global gene expression in the mouse placenta. Genomics Data, 6, 72–73. doi:10.1016/j.gdata.2015.08.022en_US
dc.identifier.urihttp://hdl.handle.net/1808/22143
dc.description.abstractThe effects of vitamin D are mediated through the vitamin D receptor (VDR), a predominantly nuclear receptor, expressed in numerous tissues including the placenta. VDR and the retinoid X receptor (RXR) form a dimer complex which binds to genomic vitamin D responsive elements located primarily in promoter regions and recruit cell-specific transcription factor complexes which regulate the expression of numerous genes. To investigate the role of VDR on regulating placental gene expression, mice heterozygous (+/−) for an ablated Vdr allele (C57Bl6 strain B6.129S4-VDRtm1Mbd/J, Jackson Laboratory) were mated to generate Vdr+/+, Vdr+/− and Vdr −/− fetuses and placental samples were collected at day 18.5 of pregnancy. RNA was isolated from placental tissue with global gene expression measured using Affymetrix Mouse Gene 2.1 ST Arrays to assess the effects of VDR on global gene expression in the placenta. All raw array data are deposited in Gene Expression Omnibus (GEO) under accession GSE61583.en_US
dc.publisherElsevieren_US
dc.rights© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectVitamin Den_US
dc.subjectPlacentaen_US
dc.subjectGene expressionen_US
dc.subjectVDRen_US
dc.titleThe effect of Vdr gene ablation on global gene expression in the mouse placentaen_US
dc.typeArticleen_US
kusw.kuauthorLaurence, Jessica A.
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.doi10.1016/j.gdata.2015.08.022en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).