Recent advances in the discovery and design of multicomponent reactions for the generation of small-molecule libraries
dc.contributor.author | Malinakova, Helena C. | |
dc.date.accessioned | 2016-11-15T17:44:44Z | |
dc.date.available | 2016-11-15T17:44:44Z | |
dc.date.issued | 2015-09-04 | |
dc.identifier.citation | Malinakova, H. C. (2015). Recent advances in the discovery and design of multicomponent reactions for the generation of small-molecule libraries. Rep Org Chem, 5, 75-90. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/21958 | |
dc.description.abstract | The current drug discovery process is dependent on the ability of synthetic chemistry to deliver libraries of small molecules with ever increasing levels of structural complexity and diversity. Sequencing multicomponent reactions (MCRs) with elaboration or cyclization steps represents an effective approach toward generating libraries of complex and diverse small molecules. This review highlights the most recent (2010–2015) examples of the application of reaction sequences including MCRs to the synthesis of diverse assemblies of small heterocycles. Sequences performed in multiple separate steps, or as one-pot operations, and including MCRs based on 1) carbonyl condensations; 2) isocyanide-based reactions; 3) cycloadditions; and 4) transition metal-mediated reactions are discussed. | en_US |
dc.publisher | Dove Medical Press | en_US |
dc.rights | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | |
dc.subject | multicomponent reactions | en_US |
dc.subject | sequential reactions | en_US |
dc.subject | tandem reactions | en_US |
dc.subject | divergent reactions | en_US |
dc.subject | heterocycles | en_US |
dc.subject | diversity | en_US |
dc.title | Recent advances in the discovery and design of multicomponent reactions for the generation of small-molecule libraries | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Malinakova, Helena C. | |
kusw.kudepartment | Chemistry | en_US |
dc.identifier.doi | 10.2147/ROC.S65115 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.