Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

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Issue Date
2015-07-15Author
Hasan, Anwarul
Khattab, Ahmad
Islam, Mohammad Ariful
Hweij, Khaled Abou
Zeitouny, Joya
Waters, Renae
Sayegh, Malek
Hossain, Monowar
Paul, Arghya
Publisher
Wiley Open Access
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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Show full item recordAbstract
Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI.
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Citation
Hasan A., Khattab A., Islam M. A., Hweij K. A., Zeitouny J., Waters R., Sayegh M., Hossain M. M., Paul A. (2015). Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction. Adv. Sci., 2: 1500122. doi: 10.1002/advs.201500122
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