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    Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

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    Paul_2015.pdf (3.107Mb)
    Issue Date
    2015-07-15
    Author
    Hasan, Anwarul
    Khattab, Ahmad
    Islam, Mohammad Ariful
    Hweij, Khaled Abou
    Zeitouny, Joya
    Waters, Renae
    Sayegh, Malek
    Hossain, Monowar
    Paul, Arghya
    Publisher
    Wiley Open Access
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Rights
    © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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    Abstract
    Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI.
    URI
    http://hdl.handle.net/1808/21818
    DOI
    https://doi.org/10.1002/advs.201500122
    Collections
    • Chemical and Petroleum Engineering Scholarly Works [126]
    Citation
    Hasan A., Khattab A., Islam M. A., Hweij K. A., Zeitouny J., Waters R., Sayegh M., Hossain M. M., Paul A. (2015). Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction. Adv. Sci., 2: 1500122. doi: 10.1002/advs.201500122

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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