The efficacy of behavioural activation treatment for co-occurring depression and substance use disorder (the activate study): a randomized controlled trial

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Issue Date
2016-07-08Author
Ross, Joanne
Teesson, Maree
Lejuez, Carl W.
Mills, Katherine
Kaye, Sharlene
Brady, Kathleen
Dore, Glenys
Prior, Katrina
Larkin, Xanthe
Cassar, Joanne
Ewer, Philippa
Memedovic, Sonja
Kihas, Ivana
Masters, Sarah Louise
Publisher
BioMed Central
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
Copyright © The Author(s). 2016
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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BackgroundEpidemiological studies suggest that compared with the general population, mood disorders are up to 4.7 times more prevalent in substance dependent samples. Comorbid substance use disorder (SUD) and depression has been associated with a more severe and protracted illness course and poorer treatment outcomes. Despite this, the development and assessment of behavioural interventions for treating depression among individuals with SUDs have received little empirical attention. Behavioural Activation Treatment for Depression (BATD-R) is an empirically supported treatment for depression that has shown some efficacy among substance users. This paper describes the study protocol of a parallel, single blind, randomised controlled trial to determine the efficacy and feasibility of a modified version of the BATD-R (Activate) in reducing symptoms of depression and substance dependence among individuals in residential rehabilitation (RR) and opioid substitution therapy (OST).Methods/designA sample of approximately 200 individuals with depressive symptomatology in treatment for SUD will be recruited from RR and OST services in New South Wales, Australia. Dynamic random allocation following minimisation methodology will be used to assign participants to one of two groups. The control group will receive treatment as usual (TAU), which will be the model of care provided in accordance with standard practice at participating RR and OST services. The intervention group will receive Activate, comprising 10 individual 60-min therapy sessions with a psychologist employed on the research team, in addition to TAU. Data collection will occur at baseline (pre-intervention), and 3-months and 12-months post baseline.DiscussionThe association between depression and substance dependence has been well documented, yet practical and effective treatments are scarce. The findings of the present study will contribute significantly to understanding the types of programs that are effective in treating this comorbidity.Trial registrationThis trial is registered with the Australian and New Zealand Clinical Trials registry, ACTRN12613000876796. Registered on 7 August, 2013.Electronic supplementary materialThe online version of this article (doi:10.1186/s12888-016-0943-1) contains supplementary material, which is available to authorized users.
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Ross, Joanne, Maree Teesson, Carl Lejuez, Katherine Mills, Sharlene Kaye, Kathleen Brady, Glenys Dore, Katrina Prior, Xanthe Larkin, Joanne Cassar, Philippa Ewer, Sonja Memedovic, Ivana Kihas, and Sarah Louise Masters. "The Efficacy of Behavioural Activation Treatment for Co-occurring Depression and Substance Use Disorder (the Activate Study): A Randomized Controlled Trial." BMC Psychiatry 16.1 (2016): n. pag. Web.
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