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dc.contributor.authorPicking, William D.
dc.contributor.authorHackstadt, T.
dc.contributor.authorParetsky, D.
dc.identifier.citationPicking, W. D., Hackstadt, T., & Paretsky, D. (1989). Endotoxicosis induced by Coxiella burnetii lipopolysaccharide stimulates a ribosomal protein S6 kinase: some properties of the partially purified enzyme. Infection and Immunity, 57(12), 3683–3688.en_US
dc.description.abstractGuinea pig endotoxicosis induced by lipopolysaccharide from Coxiella burnetii Nine Mile phase I stimulates phosphorylation of liver ribosomal protein S6, with a 50% increase at 12 h postinoculation. The responsible protein kinase (S6PK) has been partially purified from liver; its activity is independent of cyclic AMP and of Ca2+ plus phosphatidyl serine or diacylglycerol. The preparation has an apparent optimum concentration of 20 mM Mg2+, while Ca2+ and Mn2+ are each inhibitory at 2 mM. The apparent Km for ATP is 30 microM with intact ribosomes. Because of the central role of phosphorylation in metabolic regulation and a purported role of phosphorylated S6 in protein synthesis, the lipopolysaccharide-induced stimulation of S6PK suggests a significant regulatory role of such enzymes in the pathobiochemistry of Q fever infection and endotoxicosis.en_US
dc.publisherAmerican Society for Microbiologyen_US
dc.titleEndotoxicosis Induced by Coxiella burnetii Lipopolysaccharide Stimulates a Ribosomal Protein S6 Kinase: Some Properties of the Partially Purified Enzymeen_US
kusw.kuauthorPicking, William D.
kusw.kudepartmentPharmaceutical Chemistryen_US
kusw.oanotesPer SHERPA/RoMEO 7/15/2016: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: green tick author can archive publisher's version/PDF General Conditions:

Author's pre-print on recognised non profit pre-print archives Author's post-print on funder's repositories, institutional repository or subject-based repositories Non-commercial Publisher's version/PDF may be used Publisher's version/PDF may be used on author's personal website or employers website Recommended that author's post-prints submitted to PubMed or institutional repositories are made available 6 months after publication Author's pre-print must be updated with citation and DOI upon publication
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item does not meet KU Open Access policy criteria.en_US

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