Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols
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Issue Date
2011-09-21Author
El-Gendy, Nashwa
Parnputtapitak, Warangkana
Berkland, Cory J.
Publisher
Wiley
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Metadata
Show full item recordAbstract
Particle engineering strategies remain at the forefront of aerosol research for localized treatment of lung diseases and represent an alternative for systemic drug therapy. With the hastily growing popularity and complexity of inhalation therapy, there is a rising demand for tailor-made inhalable drug particles capable of affording the most proficient delivery to the lungs and the most advantageous therapeutic outcomes. To address this formulation demand, nanoparticle agglomeration was used to develop aerosols of the asthma therapeutics, fluticasone or albuterol. In addition, a combination aerosol was formed by drying agglomerates of fluticasone nanoparticles in the presence of albuterol in solution. Powders of the single drug nanoparticle agglomerates or of the combined therapeutics possessed desirable aerodynamic properties for inhalation. Powders were efficiently aerosolized (~75% deposition determined by cascade impaction) with high fine particle fraction and rapid dissolution. Nanoparticle agglomeration offers a unique approach to obtain high performance aerosols from combinations of asthma therapeutics.
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This is the author's accepted manuscript. Made available by the permission of the publisher.
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Citation
El-Gendy, Nashwa, Warangkana Pornputtapitak, and Cory Berkland. "Nanoparticle Agglomerates of Fluticasone Propionate in Combination with Albuterol Sulfate as Dry Powder Aerosols." European Journal of Pharmaceutical Sciences 44.4 (2011): 522-33. doi:10.1016/j.ejps.2011.09.014.
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