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University of Kansas Medical Center: Recent submissions
Now showing items 261-280 of 1047
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Regulation of human trophoblast syncytialization by histone demethylase LSD1
(University of Kansas, 2016-12-31)A successful pregnancy is critically dependent upon proper placental development and function, beginning with differentiation of human trophoblast cells. At the final stage of trophoblast differentiation, the human placenta ... -
RNA-Seq Analysis Strategies and Ethical Considerations Involved in Precision Medicine
(University of Kansas, 2016-12-31)RNA-Seq has become the most recently and widely accepted method to evaluate gene expression. Though with RNA-Seq being a fairly green technology, analytical methods for its output data have not been fully investigated as ... -
Beta-catenin Associated Protein Complex Maintains Ground State Mouse Embryonic Stem Cell by Regulating Germline Development
(University of Kansas, 2016-12-31)Mouse embryonic stem (ES) cells cultured in defined medium with MEK and GSK3 inhibitors(2i) resemble the pre-implantation epiblast in the ground state, with full development capacity including the somatic lineages and the ... -
Observations on the early developments of the white rat (Rattus norvegicus albinus)
(University of Kansas, 1930) -
Advance Care Planning in the Marital Context: Dyadic Analyses of Advance Directive Completion by Older Married Adults
(University of Kansas, 2016-12-31)Advance directive completion is associated with higher quality care at the end of life and increased odds of receiving hospice care and of dying at home. Researchers seeking to understand why some older adults complete ... -
The effects of prolonged administrations of methyl guanidine sulphate on the blood pressures of non-anesthetized dogs
(University of Kansas, 1930) -
The Modified Rapid Emergency Medicine Score: A Novel Trauma Triaging Tool for Predicting In-hospital Mortality
(University of Kansas, 2016-05-31)Objectives: Trauma systems currently rely on imperfect and subjective tools to prioritize responses and resources, thus there is a critical need to develop a more accurate trauma severity score. Our objective was to modify ... -
Multi-Parameter Flow Cytometric Analysis of Ikaros Family Expression in Human T Cell Development and T-ALL
(University of Kansas, 2016-05-31)The Ikaros family transcription factors are critical regulators of T cell development and leukemogenesis. Loss of function of all five family members leads to an early block in murine lymphocyte development, whereas reduced ... -
ROLES OF TMIGD3 AND A3AR IN SUPPRESSION OF OSTEOSARCOMA MALIGNANCY
(University of Kansas, 2016-05-31)Osteosarcoma (OS) is the second leading cause of cancer-related death in children and young adults. Despite advances in the treatment for OS, the survival rate of high-grade OS has reached a plateau and remains at 50-80% ... -
PRESSURE ULCERS AND PREVENTION AMONG PEDIATRIC PATIENTS AND FACTORS ASSOCIATED WITH THEIR OOCCURENCE IN ACUTE CARE HOSPITALS
(University of Kansas, 2015-08-31)Abstract Introduction: Pressure ulcers are a health-care concern for all patient populations; however, younger patients, including infants, have different etiologies associated with pressure ulcer development. The influence ... -
Residential Satisfaction, Psychological Well-Being, and Personality Traits: Effects on Relocation among Older Adults
(University of Kansas, 2014-08-31)The focus of this study is the moves made voluntarily in later life. Older adults who engage in voluntary late life relocation are more likely to be white, have better health, have higher socioeconomic status, and have ... -
CHARACTERIZATION OF THE ONTOGENY AND INTER-INDIVIDUAL VARIATION OF GENES IN CHOLESTEROL AND STATIN PATHWAYS
(University of Kansas, 2015-05-31)Introduction: Previous studies have shown that gene expression can change throughout development,1 and therefore genotype-phenotype associations found in adults might not be observed in children of all ages. The purpose ... -
Roles of piRNA Pathway Components Piwi and Aubergine In Drosophila melanogaster Female Germline Development
(University of Kansas, 2014-12-31)Recent studies have identified a new class of small RNAs with 24-30 nucleotides in length. This class of small RNAs is associated with the PIWI clade Argonaute proteins, thus named PIWI-interacting RNAs (piRNAs). piRNAs ... -
Effects of a high fat diet on brain metabolism in rats: An in vivo 1H-MRS study
(University of Kansas, 2014-12-31)Diet-induced obesity and its metabolic consequences can lead to neurological dysfunction and increase the risk of developing Alzheimer's disease (AD) and Parkinson's disease (PD). Despite these realities, the effects of a ... -
Heat Shock Proteins: Treating Metabolic Disease by Turning up the Heat
(University of Kansas, 2015-12-31)The prevalence of type 2 diabetes has risen as access to nutrition as increased and physical activity levels have decreased. Low cardiorespiratory fitness (CRF) levels are influenced by genetics, but low levels of physical ... -
Role of Drosophila Orb2 (CPEB) in Synaptic Protein Synthesis
(University of Kansas, 2015-12-31)How a transient experience creates a persistent memory remains a fundamental unresolved issue in neuroscience. One of the molecular processes that is believed to be critical for long- lasting memory is synthesis of new ... -
Effects of balance training on balance, gait and non-motor symptoms in individuals with Parkinson's disease
(University of Kansas, 2016-05-31)Postural instability (PI) is one of the most disabling symptoms of Parkinson’s disease (PD). PI is a well-known risk factor for falls in individuals with PD that worsens with disease progression. About 50-70% of people ...