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dc.contributor.authorRogers, Steven A.
dc.contributor.authorHuigens, Robert W., III
dc.contributor.authorCavanagh, John
dc.contributor.authorMelander, Christian
dc.identifier.citationRogers, S. A., R. W. Huigens, J. Cavanagh, and C. Melander. "Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents." Antimicrobial Agents and Chemotherapy 54.5 (2010): 2112-118.
dc.descriptionThis is the published version.en_US
dc.description.abstract2-Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilms. Furthermore, we document that the 2-aminoimidazole/triazole conjugate will also resensitize multidrug-resistant strains of bacteria to the effects of conventional antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii.en_US
dc.publisherAmerican Society for Microbiologyen_US
dc.titleSynergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agentsen_US
kusw.kuauthorRogers, Steven A.
kusw.kudepartmentSpecialized Chemistry Centeren_US
kusw.oanotesPer SHERPA/RoMEO, 12/31/15: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: green tick author can archive publisher's version/PDF General Conditions:

Author's pre-print on recognised non profit pre-print archives Author's post-print on funder's repositories, institutional repository or subject-based repositories Non-commercial Publisher's version/PDF may be used Publisher's version/PDF may be used on author's personal website or employers website Recommended that author's post-prints submitted to PubMed or institutional repositories are made available 6 months after publication Author's pre-print must be updated with citation and DOI upon publication
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.

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