| dc.contributor.author | Rogers, Steven A. | |
| dc.contributor.author | Huigens, Robert W., III | |
| dc.contributor.author | Cavanagh, John | |
| dc.contributor.author | Melander, Christian | |
| dc.date.accessioned | 2015-12-31T19:21:40Z | |
| dc.date.available | 2015-12-31T19:21:40Z | |
| dc.date.issued | 2010-05 | |
| dc.identifier.citation | Rogers, S. A., R. W. Huigens, J. Cavanagh, and C. Melander. "Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents." Antimicrobial Agents and Chemotherapy 54.5 (2010): 2112-118. http://dx.doi.org/10.1128/AAC.01418-09 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/19372 | |
| dc.description | This is the published version. | en_US |
| dc.description.abstract | 2-Aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilms. Furthermore, we document that the 2-aminoimidazole/triazole conjugate will also resensitize multidrug-resistant strains of bacteria to the effects of conventional antibiotics, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii. | en_US |
| dc.publisher | American Society for Microbiology | en_US |
| dc.relation.isversionof | 10.1128/AAC.01418-09 | en_US |
| dc.title | Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents | en_US |
| dc.type | Article | |
| kusw.kuauthor | Rogers, Steven A. | |
| kusw.kudepartment | Specialized Chemistry Center | en_US |
| kusw.oanotes | Per SHERPA/RoMEO, 12/31/15: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing)
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Author's pre-print must be updated with citation and DOI upon publication | en_US |
| kusw.oaversion | Scholarly/refereed, publisher version | |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | |
| dc.rights.accessrights | openAccess | |
