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    Integration of photoacoustic imaging and high-intensity focused ultrasound

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    Issue Date
    2010-03-23
    Author
    Cui, Huizhong
    Staley, Jacob W.
    Yang, Xinmai
    Publisher
    Society of Photo-optical Instrumentation Engineers
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    We have developed an integrated photoacoustic imaging (PAI) and high-intensity focused ultrasound (HIFU) system for solid tumor treatments. A single-element, spherically focused ultrasonic transducer, with a central frequency of 5 MHz, was used to induce HIFU lesions in soft tissue. The same ultrasonic transducer was also used as a detector during PAI to guide HIFU ablation. The use of same transducer for PAI and HIFU can reduce the requirement on acoustic windows during the imaging guided therapy, as well as ensuring the correct alignment between the therapeutic beam and the planned treatment volume. During an experiment, targeted soft tissue was first imaged by PAI. The resulted image was used to plan the subsequent HIFU ablation. After the HIFU ablation, targeted soft tissue was imaged again by PAI to evaluate the effectiveness of treatments. Good contrast was obtained between photoacoustic images before and after HIFU ablation. In conclusion, our results demonstrated that PAI technology may potentially be integrated with HIFU ablation for image-guided therapy.
    Description
    This is the published version.
    URI
    http://hdl.handle.net/1808/19357
    DOI
    https://doi.org/10.1117/1.3365948
    Collections
    • Bioengineering Program Scholarly Works [144]
    • Mechanical Engineering Scholarly Works [135]
    Citation
    Cui, Huizhong, Jacob Staley, and Xinmai Yang. "Integration of Photoacoustic Imaging and High-intensity Focused Ultrasound." J. Biomed. Opt. Journal of Biomedical Optics 15.2 (2010): 021312. http://dx.doi.org/10.1117/1.3365948.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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