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    Functional photoacoustic imaging to observe regional brain activation induced by cocaine hydrochloride

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    Jo_photoacoustic_imaging2011.pdf (832.8Kb)
    Issue Date
    2011-09-13
    Author
    Jo, Janggun
    Yang, Xinmai
    Publisher
    Society of Photo-optical Instrumentation Engineers (SPIE)
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Photoacoustic microscopy (PAM) was used to detect small animal brain activation in response to drug abuse. Cocaine hydrochloride in saline solution was injected into the blood stream of Sprague Dawley rats through tail veins. The rat brain functional change in response to the injection of drug was then monitored by the PAM technique. Images in the coronal view of the rat brain at the locations of 1.2 and 3.4 mm posterior to bregma were obtained. The resulted photoacoustic (PA) images showed the regional changes in the blood volume. Additionally, the regional changes in blood oxygenation were also presented. The results demonstrated that PA imaging is capable of monitoring regional hemodynamic changes induced by drug abuse.
    Description
    This is the published version. copyright 2011 Society of Photo-optical Instrumentation Engineers (SPIE)
    URI
    http://hdl.handle.net/1808/18987
    DOI
    https://doi.org/10.1117/1.3626576
    Collections
    • Bioengineering Scholarly Works [127]
    • Mechanical Engineering Scholarly Works [114]
    Citation
    Jo, Janggun, and Xinmai Yang. "Functional Photoacoustic Imaging to Observe Regional Brain Activation Induced by Cocaine Hydrochloride." J. Biomed. Opt. Journal of Biomedical Optics 16.9 (2011): 090506. http://dx.doi.org/10.1117/1.3626576

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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